ID D4ABR1_RAT Unreviewed; 783 AA.
AC D4ABR1;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G6 {ECO:0000313|Ensembl:ENSRNOP00000026441.7};
GN Name=Plekhg6 {ECO:0000313|Ensembl:ENSRNOP00000026441.7,
GN ECO:0000313|RGD:2318544};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000026441.7, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000026441.7, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000026441.7,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000026441.7}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000026441.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002726493.2; XM_002726447.5.
DR RefSeq; XP_002729474.2; XM_002729428.5.
DR RefSeq; XP_006225110.1; XM_006225048.3.
DR RefSeq; XP_006237465.1; XM_006237403.3.
DR AlphaFoldDB; D4ABR1; -.
DR STRING; 10116.ENSRNOP00000026441; -.
DR iPTMnet; D4ABR1; -.
DR PhosphoSitePlus; D4ABR1; -.
DR PaxDb; 10116-ENSRNOP00000026441; -.
DR Ensembl; ENSRNOT00000026441.7; ENSRNOP00000026441.7; ENSRNOG00000019528.7.
DR GeneID; 100362241; -.
DR KEGG; rno:100362241; -.
DR UCSC; RGD:2318544; rat.
DR AGR; RGD:2318544; -.
DR CTD; 55200; -.
DR RGD; 2318544; Plekhg6.
DR VEuPathDB; HostDB:ENSRNOG00000019528; -.
DR eggNOG; KOG3521; Eukaryota.
DR GeneTree; ENSGT00940000161250; -.
DR HOGENOM; CLU_021968_1_0_1; -.
DR InParanoid; D4ABR1; -.
DR OMA; SPWESSE; -.
DR TreeFam; TF316755; -.
DR Reactome; R-RNO-8980692; RHOA GTPase cycle.
DR Reactome; R-RNO-9013149; RAC1 GTPase cycle.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000019528; Expressed in jejunum and 18 other cell types or tissues.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13244; PH_PLEKHG5_G6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042918; PLEKHG6.
DR PANTHER; PTHR47671; PLECKSTRIN DOMAIN-CONTAINING FAMILY G MEMBER 6; 1.
DR PANTHER; PTHR47671:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 6; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 158..350
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 406..506
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 60..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 88755 MW; 4A3619443A4009D9 CRC64;
MQTFDPPNEG PLQGLVASRI ETYGGRHQTS AQSSAGITYP RGGPALDLSR RRLQHYVPFA
KGSGQTRGLS PQEPDPEKRH GNYFGVGSPY FPKFKEVSKA HELEVRLHTF SMFGMPRLPP
EDRRHWEIGE GGDSALTIEK SWKELVLGHK EMNRELCHQQ EALWELLTTE LIYLRKLKIM
TDLLAAGLLN LQRVGLLTEV SAETLFGNVP KLIRTHRRFW EEVLQPILED TRTSGQPLDP
VSLQNGFLTF GQRFQPYIQY CLRVKQTMAY AREQQDTNPL FRTFVQWCEK HKRSGRQTLG
DLLIKPHQRI TKYPLLLQAV LKRSPEPRAQ LALDNMIVAV ESFLQHINGL VRRGEEQESL
MAVAQRIGPY EVLEPSSEEV EKHLRQFSTL DLMTPIEGVA PENTRQLLLE GPVRMKEGRE
GKMDVYLFLF SDVLLVTKPQ RKVDKAKVIR PPLMLEKLVC RPLRDPHSFL LIHLTEFQCV
SSALTVHCSS STERTQWLQK TQQAQATLQK LKAEEYVQQK RGLLALYRDQ GRESPSPRPS
TPSPEDSQSS AEGRALEFTV IPRLVVTEDT DEDTPSVTDD TSDSGYGTLI PSSPKDSQSP
LNRLRSKALR RDPRLTFSTL ELRDVPLRPQ PPDPQALQRR SAPEMPEGIL RGGSLPRRAP
PTWSEEEDET LTPGNVVVET LSRAQRRSPL PHSPAHTDSA GESPWESTDE DEGPLSPGLR
PRSLRAEDML REIREELASQ RIEGALEPEP GNGKLRRLTR AQLQRMRGHH VIQLDTPMST
SDV
//
