ID   D4AUK5_ARTBC            Unreviewed;       748 AA.
AC   D4AUK5;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   22-FEB-2023, entry version 55.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=ARB_07922 {ECO:0000313|EMBL:EFE33170.1};
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE33170.1, ECO:0000313|Proteomes:UP000008866};
RN   [1] {ECO:0000313|Proteomes:UP000008866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFE33170.1}.
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DR   EMBL; ABSU01000011; EFE33170.1; -; Genomic_DNA.
DR   RefSeq; XP_003013810.1; XM_003013764.1.
DR   AlphaFoldDB; D4AUK5; -.
DR   STRING; 663331.D4AUK5; -.
DR   GeneID; 9521228; -.
DR   KEGG; abe:ARB_07922; -.
DR   eggNOG; KOG2166; Eukaryota.
DR   HOGENOM; CLU_004747_7_1_1; -.
DR   OMA; MFKDMTI; -.
DR   OrthoDB; 5474206at2759; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008866}.
FT   DOMAIN          427..670
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          348..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          715..735
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        717..735
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   748 AA;  85446 MW;  EEBD20D6D7F27637 CRC64;
     MTGRNENDDF ASIWNILASS IREIHTKNSS QLSFEELYRN AYKLVLRKQA MDLYEKVAEL
     EKDWLYNDVR KQVASLITPA LLTITDSADA TEHANERKAA GERLLAKLKE VWEDHQLCMG
     MITDVLMYMD RVVMQELRSQ SIYDTSMGLF RDCVLRADIG GENGTIGSVF ENTLLFMILL
     EREGVIIDRT LIKHCVYLLE GLYEDGIEDS TGKLYHTTFE PAYLEASRRY YAAEGQRLLT
     TTDAATFCKR VTARIRAEQS LCQQTLSPVT EAKVMEVIDD CLIRHYIGEV IRMDDSGVKY
     MIQNDRLEDL KNVFELIARI DAKKVALTKV VQQTVIEYGT AVNTAAKELS QNPPAPSATD
     QGKKSSVPDE KQPVANLQTA AAIKWVDDVL KLKAKFDRIW EEAFIKDQAL QTALTLSFSD
     FINVNPRGTE YLSLFFDENL RKGIKGKTEE EVDALIDNGI TLLRYIRDKD LFETYYKKHL
     SRRLLMKRSA SMDAERQMIT KMKMEVGNTF TQRLESMFKD MAVSADLTTS YRDYIGNNSR
     IELEMSVLTS TMWPMEIMSS HNREGQVQLP CIFPKNVESL KQSFERFYLD KHSGRKLSWL
     PGMGTADIRA TFTRPNGKVE RHDLNVSTYA MVILLLFNDL PSGESLTFEE IQEKTRIPTN
     ELIRNLQSLA VAPKTRVLRK EPMSKGVQPS DKFSFNEQFT SKFTRLKIGV VSASGNKVEN
     KEERTDTEKK TSEERGNTIE AAIVRIMK
//