ID D4DD48_TRIVH Unreviewed; 865 AA.
AC D4DD48;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 22-FEB-2023, entry version 37.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=TRV_05055 {ECO:0000313|EMBL:EFE40211.1};
OS Trichophyton verrucosum (strain HKI 0517).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663202 {ECO:0000313|EMBL:EFE40211.1, ECO:0000313|Proteomes:UP000008383};
RN [1] {ECO:0000313|Proteomes:UP000008383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HKI 0517 {ECO:0000313|Proteomes:UP000008383};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE40211.1}.
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DR EMBL; ACYE01000257; EFE40211.1; -; Genomic_DNA.
DR RefSeq; XP_003020829.1; XM_003020783.1.
DR AlphaFoldDB; D4DD48; -.
DR GeneID; 9577600; -.
DR KEGG; tve:TRV_05055; -.
DR HOGENOM; CLU_005230_0_2_1; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000008383; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 426..451
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 472..489
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 580..603
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 609..628
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 648..667
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 798..821
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 101..135
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 865 AA; 98721 MW; BCB462F47512B358 CRC64;
MSPTQDTLFR SADMSLTQLY IANEIGREVV SALGELGQVQ FRDLNEETTA FQKTFTNEIR
RLDNVERQLR YFHAQMEKAD IEMRPSEEFS NNLAAPMASE IDELAERSES LEQRVSSLNE
SYEALKRREV ELIERRWVLR EAGGFFDRAH GQTDEIRQSF DNDEAPLLRD VEQQPPRGQN
GDAHQSSFSV MDIGFVAGVI PRDRIGAFER ILWRTLRGNL YMNQSEIPDP IVDPATNEEI
HKNVFVIFAH GKEIIAKIRK ISESLGANLH AVDENSELRR DQIHDVNTRL TDVGNVLRNT
KNALDAELTQ IARSLAAWMI IVKKEKAVYH ALNKFSYDQA RKTLIAEAWC PTNSLGLIKS
TLQDVNDRAG LSVPTIVNQI RTNKTPPTYM KTNKFTQSFQ LIVDAYGTSK YQEVNPGLPT
IVTFPFFFAV MFGDFGHAML MTMLAITLIL FERKLGKTKL DELSSMAFSG RYIMLMMGIF
AMYTGLIYND IFSKSMDLFQ SAWSWPEDFN ENETVFAELK GSYRYPFGLD WGWHGTDNNL
LFTNSYKMKL SIILGWSHMT YSLCQSFVNA RHFKKPIEIW GNFVPGMIFF QSIFGYLVFT
IIYKWSVDWN GLGLPAPGLL NMLIFMFLQP GRVDDELYPG QATVQKILLF VALIQVPILL
LLKPLYLRWE HNRARALGYR GLNEAAHTSA VDDDDEHQNL ISGQRDSMGD GEEGIGMVTQ
DMGEGEEHHE FEFSEEMIHQ VIHTIAADLI ILEFCLNCVS HTASYLRLWA LSLAHQQLSS
VLWSMTLGNA FLQTSPTLRV IMTVITFYLW FVLTISILCV MEGTSAMLHS LRLHWVEAMS
KHFIGDGIPF TPFSFEAILQ EDPVD
//
