ID D4FZ04_BACNB Unreviewed; 299 AA.
AC D4FZ04;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 2.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Late competence protein ComER {ECO:0000313|EMBL:BAI86085.2};
GN Name=comER {ECO:0000313|EMBL:BAI86085.2};
GN ORFNames=BSNT_09006 {ECO:0000313|EMBL:BAI86085.2};
OS Bacillus subtilis subsp. natto (strain BEST195).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=645657 {ECO:0000313|EMBL:BAI86085.2, ECO:0000313|Proteomes:UP000006805};
RN [1] {ECO:0000313|EMBL:BAI86085.2, ECO:0000313|Proteomes:UP000006805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BEST195 {ECO:0000313|EMBL:BAI86085.2,
RC ECO:0000313|Proteomes:UP000006805};
RX PubMed=20398357; DOI=10.1186/1471-2164-11-243;
RA Nishito Y., Osana Y., Hachiya T., Popendorf K., Toyoda A., Fujiyama A.,
RA Itaya M., Sakakibara Y.;
RT "Whole genome assembly of a natto production strain Bacillus subtilis natto
RT from very short read data.";
RL BMC Genomics 11:243-243(2010).
RN [2] {ECO:0000313|EMBL:BAI86085.2, ECO:0000313|Proteomes:UP000006805}
RP GENOME REANNOTATION.
RC STRAIN=BEST195 {ECO:0000313|EMBL:BAI86085.2,
RC ECO:0000313|Proteomes:UP000006805};
RX PubMed=25329997; DOI=10.1371/journal.pone.0109999;
RA Kamada M., Hase S., Sato K., Toyoda A., Fujiyama A., Sakakibara Y.;
RT "Whole genome complete resequencing of Bacillus subtilis natto by combining
RT long reads with high-quality short reads.";
RL PLoS ONE 9:E109999-E109999(2014).
CC -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC {ECO:0000256|ARBA:ARBA00005525}.
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DR EMBL; AP011541; BAI86085.2; -; Genomic_DNA.
DR AlphaFoldDB; D4FZ04; -.
DR STRING; 86029.AWV81_13305; -.
DR KEGG; bso:BSNT_09006; -.
DR HOGENOM; CLU_042344_2_1_9; -.
DR Proteomes; UP000006805; Chromosome.
DR GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:InterPro.
DR GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.10.3730.10; ProC C-terminal domain-like; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR029036; P5CR_dimer.
DR InterPro; IPR000304; Pyrroline-COOH_reductase.
DR PANTHER; PTHR11645:SF51; COME OPERON PROTEIN 4; 1.
DR PANTHER; PTHR11645; PYRROLINE-5-CARBOXYLATE REDUCTASE; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR Pfam; PF14748; P5CR_dimer; 1.
DR PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00521; P5CR; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|PIRSR:PIRSR000193-1}.
FT DOMAIN 28..123
FT /note="Pyrroline-5-carboxylate reductase catalytic N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03807"
FT DOMAIN 189..288
FT /note="Pyrroline-5-carboxylate reductase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF14748"
FT BINDING 32..37
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR000193-1"
SQ SEQUENCE 299 AA; 33273 MW; 1B5EF5DADD189792 CRC64;
MFPAFVIFYF HNTYGLEDNS SKEGKPLKIG FIGTGNMGTI LIESFIESKA ADPSNMTITN
RTIEKALHIK NRYNSINVTE SLEKLVSENE MIFICVKPLD IYPLLARALP YLRKDHILIS
ITSPVQTEQL EQYVPCQVAR VIPSITNRAL AGVSLVTFGT SCGESAKTKI NELMQHISHP
LQIESDITRV ASDIVSCGPA FMSYLIQRFI DAAVSETSVS KQDAILMCKE MLVGMGKLLE
TELYTLPALQ EKVCVKGGVT GEGIKALESG VQDMFHRVFQ NTHMKYEEDI SAVKKQFHV
//
