ID D4GP15_HALVD Unreviewed; 837 AA.
AC D4GP15; L9VIJ7;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Folate-binding FAD-dependent oxidoreductase {ECO:0000313|EMBL:ADE01633.1};
GN Name=dmg1 {ECO:0000313|EMBL:ADE01633.1};
GN OrderedLocusNames=HVO_B0014 {ECO:0000313|EMBL:ADE01633.1};
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OG Plasmid pHV3 {ECO:0000313|EMBL:ADE01633.1,
OG ECO:0000313|Proteomes:UP000008243}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800 {ECO:0000313|EMBL:ADE01633.1, ECO:0000313|Proteomes:UP000008243};
RN [1] {ECO:0000313|EMBL:ADE01633.1, ECO:0000313|Proteomes:UP000008243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 /
RC VKM B-1768 / DS2 {ECO:0000313|Proteomes:UP000008243};
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; CP001953; ADE01633.1; -; Genomic_DNA.
DR RefSeq; WP_004041140.1; NZ_AOHU01000021.1.
DR AlphaFoldDB; D4GP15; -.
DR PaxDb; 309800-C498_01685; -.
DR EnsemblBacteria; ADE01633; ADE01633; HVO_B0014.
DR GeneID; 8919270; -.
DR KEGG; hvo:HVO_B0014; -.
DR PATRIC; fig|309800.29.peg.323; -.
DR eggNOG; arCOG00755; Archaea.
DR eggNOG; arCOG00756; Archaea.
DR HOGENOM; CLU_007884_11_2_2; -.
DR OrthoDB; 2001at2157; -.
DR Proteomes; UP000008243; Plasmid pHV3.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Plasmid {ECO:0000313|EMBL:ADE01633.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008243}.
FT DOMAIN 14..383
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 395..446
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 448..726
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 751..829
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 837 AA; 92503 MW; 292337D320AB5218 CRC64;
MNTWSTFPER AGTVVVGAGC VGCSAAYHLA ESGREDVVVL DRGPLFETGG STSHAPGLVF
QTAGNKLMTE MASYTRDLYD GFGDFRTCGG IEVAYTEDRW DFLKRKREWG QSYGIDEGQL
LTPEEVESRV PQINADVIYG GYYVPSDGKA DAVSAAESMA EEAREAGVEF YGHTEVTDID
TTDGSVDAVE TEHGRIEADE VLVATNIWGP LFGEMVGTDI PLVPCAHQYL VSDELDELEG
AEREIEQPLL RHQDHSLYYR QHGERYGIGS YNHESLLVDP ADIYGPDKLD DLGLEYPSLR
EFTEEHFYEN THPDHDRSAF DAASELVPGF EDCEWTSAIN GMFSFTPDGM PILGPDEDTE
GLWWALAVWV TQSGGAGDIV ASWMEDGTPR LDGSRVNASG AHVSRFQSHT GSREYTYGRG
AQQYREVYQL VHPREQPDGQ RALRRSPFYD RQADLGAEFY DSDGWEVPQW YESNETLLET
YDVPDRPDWL SQNWSKVQGA EHQHLREKVG MVDMTTFTPI EVSGPGALEF LQGLLTNDMD
VTPGRMRYSA MLNEDGGVLA DLTVARLGDE RFVLFTGGGS SATLHSRWVT EHAPDDGSVD
VTAHVSSRTG IGVFGPDSRK VLSDLVEADL SNDEFPFYSA QETYLGSIPV TMLRLSYAGE
LGWEIYAPTE YGSQLWDAIR EAGEEYDIAP VGWAALDSTS MEKGFRLWGT DLTPEHNPYE
AGIGFAADLD TDFVGKAALV ADKNDDSPSD RIVPITLDEE EAVVDAGHPV FVDDEVVGYC
CRADYGYTID AGIAYAYLPE EYASSGQDVE IRYEGDAHPA TVRSGPLFDP DRDKMIR
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