ID D4GPP0_HALVD Unreviewed; 387 AA.
AC D4GPP0;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Formaldehyde dehydrogenase {ECO:0000313|EMBL:ADE01293.1};
DE EC=1.2.1.46 {ECO:0000313|EMBL:ADE01293.1};
GN Name=fdh {ECO:0000313|EMBL:ADE01293.1};
GN OrderedLocusNames=HVO_B0239 {ECO:0000313|EMBL:ADE01293.1};
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OG Plasmid pHV3 {ECO:0000313|EMBL:ADE01293.1,
OG ECO:0000313|Proteomes:UP000008243}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800 {ECO:0000313|EMBL:ADE01293.1, ECO:0000313|Proteomes:UP000008243};
RN [1] {ECO:0000313|EMBL:ADE01293.1, ECO:0000313|Proteomes:UP000008243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 /
RC VKM B-1768 / DS2 {ECO:0000313|Proteomes:UP000008243};
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP001953; ADE01293.1; -; Genomic_DNA.
DR AlphaFoldDB; D4GPP0; -.
DR PaxDb; 309800-C498_02435; -.
DR EnsemblBacteria; ADE01293; ADE01293; HVO_B0239.
DR KEGG; hvo:HVO_B0239; -.
DR eggNOG; arCOG01459; Archaea.
DR HOGENOM; CLU_026673_11_3_2; -.
DR Proteomes; UP000008243; Plasmid pHV3.
DR GO; GO:0018467; F:formaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08282; PFDH_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ADE01293.1}; Plasmid {ECO:0000313|EMBL:ADE01293.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008243};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 27..137
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 187..256
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 387 AA; 41601 MW; CDD72135F5513374 CRC64;
MSMDAVVYKG EREVAVEAVE EPQIQHPNDV VIDITTTCIC GSDLHMYEGR TAAEPGIVFG
HENMGIVEEV GDAVSSLEVG DRVVAPFNVA CGFCENCENG YTGFCTNVNP GFAGGAYGYV
AMGPYQGGQA EKLRIPYADF NALKLPDGRE HEDSFALLAD IFPTGWHGTE LANLESGDSV
AIYGAGPVGL MTAYSAKLKG AAEIYVVDRV PSRLALAEEH CDATPINFEE GDPVEQIKEI
HGGGVDKGVD AVGYQAIDPE KEADSAYDPA RENPAVVINN LIRTVRPTGE LGIPGLYVPD
DPGAPDEMAA QGRLGIDFGL LFEKGQALGT GQCNVKEYNR QLRDMIIEGR ADPSWVVSHR
VGLEDAPEMY EKFDNREEGV TKVLLEP
//
