ID D4GQW4_HALVD Unreviewed; 388 AA.
AC D4GQW4; L9V302;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=glucarate dehydratase {ECO:0000256|ARBA:ARBA00011973};
DE EC=4.2.1.40 {ECO:0000256|ARBA:ARBA00011973};
GN OrderedLocusNames=HVO_A0287 {ECO:0000313|EMBL:ADE02197.1};
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OG Plasmid pHV4 {ECO:0000313|EMBL:ADE02197.1,
OG ECO:0000313|Proteomes:UP000008243}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800 {ECO:0000313|EMBL:ADE02197.1, ECO:0000313|Proteomes:UP000008243};
RN [1] {ECO:0000313|EMBL:ADE02197.1, ECO:0000313|Proteomes:UP000008243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 /
RC VKM B-1768 / DS2 {ECO:0000313|Proteomes:UP000008243};
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O;
CC Xref=Rhea:RHEA:14573, ChEBI:CHEBI:15377, ChEBI:CHEBI:30612,
CC ChEBI:CHEBI:42819; EC=4.2.1.40;
CC Evidence={ECO:0000256|ARBA:ARBA00001426};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005183}.
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DR EMBL; CP001955; ADE02197.1; -; Genomic_DNA.
DR RefSeq; WP_004043202.1; NZ_AOHU01000058.1.
DR AlphaFoldDB; D4GQW4; -.
DR PaxDb; 309800-C498_10076; -.
DR EnsemblBacteria; ADE02197; ADE02197; HVO_A0287.
DR GeneID; 8923516; -.
DR KEGG; hvo:HVO_A0287; -.
DR PATRIC; fig|309800.29.peg.1959; -.
DR eggNOG; arCOG01168; Archaea.
DR HOGENOM; CLU_030273_3_2_2; -.
DR OrthoDB; 42605at2157; -.
DR Proteomes; UP000008243; Plasmid pHV4.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd03316; MR_like; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR034593; DgoD-like.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR PANTHER; PTHR48080; D-GALACTONATE DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR48080:SF4; GLUCARATE DEHYDRATASE; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Plasmid {ECO:0000313|EMBL:ADE02197.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008243}.
FT DOMAIN 164..262
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 388 AA; 42480 MW; 725F72942CDAFD89 CRC64;
MEITDVTAVT VDVPLTSTDE HLGIAPYTTN HGELESMERV LVRVDTDEGI EGWGEMRVFL
SPTATESLIE DGIGPMVVGQ SPFEIERLRR QVFVEYTNVD MFFSAVETAC WDIVGKALDR
PVYELLGGWT APTQSTLQHR SHVADGTRNP GPVPVAFCLG ILPPEESRVK AREALDAGFD
VLKTKAGRDW RQDVARIKAM HDETDGQLEF RLDPNQGWTL DQAVRVGAML EDEGIYLQYL
EQPIRVDSHV SLARLRQRLR QPIAPNEDTY VPHNISSLVE AGAMDVGVID LTPAGGISGI
RQQAAILEDA GVPFTHHCAF DLGIRTAAIL HAVSGIPGFS LPPDSTYYAW EGDVISEPFE
VEDGCLPAPL GPGLGISVDR DAVEAYRI
//
