ID D4GRA7_HALVD Unreviewed; 466 AA.
AC D4GRA7; L9VPT6;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=rad25a {ECO:0000313|EMBL:ADE02086.1};
GN OrderedLocusNames=HVO_A0441 {ECO:0000313|EMBL:ADE02086.1};
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OG Plasmid pHV4 {ECO:0000313|EMBL:ADE02086.1,
OG ECO:0000313|Proteomes:UP000008243}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800 {ECO:0000313|EMBL:ADE02086.1, ECO:0000313|Proteomes:UP000008243};
RN [1] {ECO:0000313|EMBL:ADE02086.1, ECO:0000313|Proteomes:UP000008243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 /
RC VKM B-1768 / DS2 {ECO:0000313|Proteomes:UP000008243};
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; CP001955; ADE02086.1; -; Genomic_DNA.
DR RefSeq; WP_004040802.1; NZ_AOHU01000013.1.
DR AlphaFoldDB; D4GRA7; -.
DR IntAct; D4GRA7; 1.
DR PaxDb; 309800-C498_00080; -.
DR EnsemblBacteria; ADE02086; ADE02086; HVO_A0441.
DR GeneID; 8923762; -.
DR KEGG; hvo:HVO_A0441; -.
DR PATRIC; fig|309800.29.peg.7; -.
DR eggNOG; arCOG00874; Archaea.
DR HOGENOM; CLU_008213_6_0_2; -.
DR OrthoDB; 11644at2157; -.
DR Proteomes; UP000008243; Plasmid pHV4.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17926; DEXHc_RE; 1.
DR Gene3D; 3.40.1170.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR040699; XPB_DRD.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18458; XPB_DRD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:ADE02086.1};
KW Helicase {ECO:0000313|EMBL:ADE02086.1};
KW Hydrolase {ECO:0000313|EMBL:ADE02086.1};
KW Nucleotide-binding {ECO:0000313|EMBL:ADE02086.1};
KW Plasmid {ECO:0000313|EMBL:ADE02086.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008243}.
FT DOMAIN 94..242
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 332..466
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 466 AA; 53248 MW; DBCEC152ADF2EF58 CRC64;
MRIEFDDGTL LLRDASDDTP YAEWDDRVDE YRAQAYRYRP LLEWAGVWAD KNEQSTLQDG
FDHALEDAAR AYPALDLTPA LHIEPRDYQQ AALDAWTNHN RRGSVVLPTG SGKTFLGLQA
IADAGVGALV VTPTIDLMNQ WHATLTNAFG DQLPEPIGVL GGGSHDVTAI TVTTYDSAYR
YVNEYGDQFG LLVVDEEHHL PPPTYRQIPE MTIAPYRLGL TATYERPDGK HELLEDLLGP
VVYREHVDDL AGEYLSEYET IHMSVDLTAD ERETYDEEYK LYRDYVDSHD FDLWKERGYQ
EFLKRTSYDP QGRRALIAKQ RAERLARTAT KKLDTLDNLI KRHHDDRAII FTANNDFAYE
ISQEFIVPCI THQTKTDERT EILERFRTGE YSMLATSQVL DEGIDVPAAN VGIILSGSAS
KRQYAQRLGR ILRPTDDRQP ARLYEIITED TMETYVSQRR REGVNA
//
