ID D4GVW5_HALVD Unreviewed; 462 AA.
AC D4GVW5; L9V8S7;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Xanthine/uracil permease family transport protein {ECO:0000313|EMBL:ADE03519.1};
GN Name=uraA2 {ECO:0000313|EMBL:ADE03519.1};
GN OrderedLocusNames=HVO_2249 {ECO:0000313|EMBL:ADE03519.1};
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800 {ECO:0000313|EMBL:ADE03519.1, ECO:0000313|Proteomes:UP000008243};
RN [1] {ECO:0000313|EMBL:ADE03519.1, ECO:0000313|Proteomes:UP000008243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 /
RC VKM B-1768 / DS2 {ECO:0000313|Proteomes:UP000008243};
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; CP001956; ADE03519.1; -; Genomic_DNA.
DR RefSeq; WP_004042137.1; NZ_AOHU01000041.1.
DR AlphaFoldDB; D4GVW5; -.
DR STRING; 309800.HVO_2249; -.
DR PaxDb; 309800-C498_06518; -.
DR EnsemblBacteria; ADE03519; ADE03519; HVO_2249.
DR GeneID; 8924048; -.
DR KEGG; hvo:HVO_2249; -.
DR PATRIC; fig|309800.29.peg.1276; -.
DR eggNOG; arCOG02805; Archaea.
DR HOGENOM; CLU_017959_8_0_2; -.
DR OrthoDB; 76842at2157; -.
DR Proteomes; UP000008243; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015851; P:nucleobase transport; IEA:InterPro.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; NF037981; NCS2_1; 1.
DR NCBIfam; TIGR03173; pbuX; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008243};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 31..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 462 AA; 46788 MW; 4DDE825529ADB75A CRC64;
MADESGELGL EYEIDDRPPL LESILLGIQH VSVMIVPATA VAFIVAGAVG LGVADTAYVV
QMVLLFSGLA TVVQAYAVGP VGSRLPIVMG TSFTFVGAAT TIGIDYGLSA VFGAILVTGF
LVEGLIGWQF DRIKPFFPPL VTGLVVVIIG LYLVPVGMDY AAGGVGAADY GATHNIGLAA
LVLGVAIALN LFTDGITRLL STLVGIAVGY AVAVPLGVVD FSPIADAAWF AIPQPGAFGV
TFEPVPIVTF AFLFLVSAME TVGDMSGITA AEGRNPTDEE FRGGLFTDGL MSSVASVFGA
FPVTSFSQNV GIVNFTGVMS RYVVGIAGVV LAVLGLSPKV GAAVATIPSA VFGGAVLLMA
GMVAASGVRL VFLHTNLDRR NMVVVAASLG LGLGVATRPD ALSGLPQAAA TFFGEPVIVT
ALTALVLNTL APGDQSPLFD AADESVAADA ADGADGRAST DD
//
