ID   D4KQT8_9FIRM            Unreviewed;       365 AA.
AC   D4KQT8;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:CBL09240.1};
DE            EC=1.3.1.12 {ECO:0000313|EMBL:CBL09240.1};
GN   ORFNames=ROI_22370 {ECO:0000313|EMBL:CBL09240.1};
OS   Roseburia intestinalis M50/1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=657315 {ECO:0000313|EMBL:CBL09240.1, ECO:0000313|Proteomes:UP000008807};
RN   [1] {ECO:0000313|EMBL:CBL09240.1, ECO:0000313|Proteomes:UP000008807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M50/1 {ECO:0000313|EMBL:CBL09240.1,
RC   ECO:0000313|Proteomes:UP000008807};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT   "The genome sequence of Roseburia intestinalis M50/1.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL09240.1, ECO:0000313|Proteomes:UP000008807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M50/1 {ECO:0000313|EMBL:CBL09240.1,
RC   ECO:0000313|Proteomes:UP000008807};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
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DR   EMBL; FP929049; CBL09240.1; -; Genomic_DNA.
DR   AlphaFoldDB; D4KQT8; -.
DR   KEGG; rim:ROI_22370; -.
DR   PATRIC; fig|657315.3.peg.3365; -.
DR   HOGENOM; CLU_055968_2_1_9; -.
DR   Proteomes; UP000008807; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CBL09240.1}.
FT   DOMAIN          4..291
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   365 AA;  40033 MW;  958629ADCD9C13A2 CRC64;
     MSLQKIGFIG LGLIGGSIAK KLHALHPELT MIATAHHAET VAEAFKEHLI INNTPCELKD
     FADCDYIFLC TPTKKNIEYL QQLKDVISPD CIITDVGSVK SEIHREVIRL GLEANFIGGH
     PMAGSEKTGL SNASETLLEN AYYIITPTTK SPSPAVEELT GLVRSLGAIP LVLGYEQHDY
     ATAAISHLPH VIAYSLVNLV RESDDENEIM KTIAAGGFKD ITRIASSSPV MWENICLSNQ
     EQILKLLDNY IHTLEVMRTN IADADSPALL DAFTAAKDYR DSITITAKGA LKNVYELYLD
     LIDETGGIAT VATILASNNL SIKNIGIIHN REFEGGVLRL EMYDGESLAL AVTLLKKHHY
     TIYER
//