ID D4KYX7_9FIRM Unreviewed; 567 AA.
AC D4KYX7;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Cysteine protease {ECO:0000313|EMBL:CBL12567.1};
GN ORFNames=RO1_20300 {ECO:0000313|EMBL:CBL12567.1};
OS Roseburia intestinalis XB6B4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=718255 {ECO:0000313|EMBL:CBL12567.1, ECO:0000313|Proteomes:UP000008953};
RN [1] {ECO:0000313|EMBL:CBL12567.1, ECO:0000313|Proteomes:UP000008953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XB6B4 {ECO:0000313|EMBL:CBL12567.1,
RC ECO:0000313|Proteomes:UP000008953};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Bernalier A.;
RT "The genome sequence of Roseburia intestinalis XB6B4.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL12567.1, ECO:0000313|Proteomes:UP000008953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XB6B4 {ECO:0000313|EMBL:CBL12567.1,
RC ECO:0000313|Proteomes:UP000008953};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; FP929050; CBL12567.1; -; Genomic_DNA.
DR AlphaFoldDB; D4KYX7; -.
DR KEGG; rix:RO1_20300; -.
DR PATRIC; fig|718255.3.peg.3202; -.
DR HOGENOM; CLU_021680_0_1_9; -.
DR Proteomes; UP000008953; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02619; Peptidase_C1; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR012854; Cu_amine_oxidase-like_N.
DR InterPro; IPR040528; Lectin-like.
DR InterPro; IPR036582; Mao_N_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF07833; Cu_amine_oxidN1; 1.
DR Pfam; PF18560; Lectin_like; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF55383; Copper amine oxidase, domain N; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CBL12567.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:CBL12567.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 178..398
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 567 AA; 63645 MW; B8D0D3166E22B892 CRC64;
MHYSKRFIAF GGIVAIAFLI KYNIPGAEYE QIGSFRGASL EAETWNPLIA SSVNDNLLSV
IIDNKQYTNE KYKFYMDDNL DIMMPVSILR DALNCSAHIY DGDRLVVEKH SSNISFSLDQ
ETATVNGDIE KIISPFTMID NEYYVSLNDL SQYMDYTYSW NMQENEAQAA DNSDASIVPT
SYDLRTKNRT SEVRNQGSYG TCWSFAALGA LESSLLPEES EQYSVDHMTL CNGFNMTQND
GGEYTMGMAY LAAWKGPVYE KDDPYGDNQT NEDLTAVKHV QEMQIIESKD YEKIKEAVFK
YGGVQTSIYN ALRSSQSSSP YYNKSTDAYC YIGTEKPNHD VVIVGWDDSY SKDNFNTDLE
GDGAFICQNS WGDNFGENGF FYISYYDTNI GTHNVVYTDI ENTDNYDHIY QSDLCGWVGQ
LGYNKDSIYG ANVFTAEGNE TLKAASFYAT GKDSQYELYV VRQFEDETSL EKMIPVASGK
LGNAGYYTVD FNQGIEVDAG ERYAVVLYII TPGSVHPMAI EYAADEATEN VDLDDGESYI
SANGSKWVSV DTVEKSNLCI KAFSDNR
//
