ID D4L2I6_9FIRM Unreviewed; 823 AA.
AC D4L2I6;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Molecular chaperone, HSP90 family {ECO:0000313|EMBL:CBL13826.1};
GN ORFNames=RO1_35670 {ECO:0000313|EMBL:CBL13826.1};
OS Roseburia intestinalis XB6B4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=718255 {ECO:0000313|EMBL:CBL13826.1, ECO:0000313|Proteomes:UP000008953};
RN [1] {ECO:0000313|EMBL:CBL13826.1, ECO:0000313|Proteomes:UP000008953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XB6B4 {ECO:0000313|EMBL:CBL13826.1,
RC ECO:0000313|Proteomes:UP000008953};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Bernalier A.;
RT "The genome sequence of Roseburia intestinalis XB6B4.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL13826.1, ECO:0000313|Proteomes:UP000008953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XB6B4 {ECO:0000313|EMBL:CBL13826.1,
RC ECO:0000313|Proteomes:UP000008953};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR EMBL; FP929050; CBL13826.1; -; Genomic_DNA.
DR AlphaFoldDB; D4L2I6; -.
DR KEGG; rix:RO1_35670; -.
DR PATRIC; fig|718255.3.peg.940; -.
DR HOGENOM; CLU_343841_0_0_9; -.
DR Proteomes; UP000008953; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR PANTHER; PTHR11528:SF97; ENDOPLASMIN; 1.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF01966; HD; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 46..291
FT /note="HD/PDEase"
FT /evidence="ECO:0000259|SMART:SM00471"
SQ SEQUENCE 823 AA; 95824 MW; 6AE75937E36EB1A8 CRC64;
MIEKVQESHL YMWLKEKDSK FLSKLDETIE YANTILPQIN NVFASYTVHG VRHSINVMEY
MYALVVDINK LSELEVALLI YSALLHDIGM IANVDEIKEI KADHAILGER KYSKVLEKYG
DEMTALQECV RPVHGKRARD YIETKMDERL FLIPESTNIS FKSELAQICM SHNEDFEWIK
KNLHNDEKKG HFDLNAQYIS VLLRISDYLD IDEQRAPLYL YKYLNPKEFS DLEWKQHFVI
ENYDKIRRNP KTNELEIFFQ GTSQDPSVHR KLLKYFDAIN GELKNAVDLC ESFVDEKYLL
PLKTNVVNQI QSKGFSFSDL RLSLDYNAVT NLLMGEHIYG DRKYGLRELI QNSIDACKTM
EESATKMEKF RYQNYQPYIS VILDKDRKKV MVMDNGSGMS IDILKKYFLN VGVSYYASDD
YRLQDREYSP IGHYGIGFLA CFMLSDKVEV NTVYYNEQKM NRISFERNSE YICLTYEDTV
RQQGTEIILD YDQCLSVFNN NIERLVSFIE NNFLDCGIPI KISTMEKGVS MPLECNIKRI
ETIIAENICL SEYLSGIEAF IDCSYKQINF AKYLSDINGY ESYCYNEEEY SVDEENISIK
NFVKDGKITF LKIPIITEDE ESEFLKAYDV LEDYQEALDK IGNYEAINIW GDEDEFEDYD
FIIEESSESI IGGYTLGGFR NQFHHGSLTP VKPEIIKKGV VTGESNAVLP YNEENTFKGR
FRWENTDTCY VKNVLLSGLR IKIPYLVDGV ILKGAVINIF NREFIPNVSR NNISASQQEK
LSYAIGKAIH LWIRDHAELS TEQKALLDVF IETKYKETNY CLR
//
