ID   D4L3D5_9FIRM            Unreviewed;       729 AA.
AC   D4L3D5;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   SubName: Full=Anaerobic ribonucleoside-triphosphate reductase {ECO:0000313|EMBL:CBL14125.1};
DE            EC=1.17.4.2 {ECO:0000313|EMBL:CBL14125.1};
GN   ORFNames=RO1_39080 {ECO:0000313|EMBL:CBL14125.1};
OS   Roseburia intestinalis XB6B4.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=718255 {ECO:0000313|EMBL:CBL14125.1, ECO:0000313|Proteomes:UP000008953};
RN   [1] {ECO:0000313|EMBL:CBL14125.1, ECO:0000313|Proteomes:UP000008953}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XB6B4 {ECO:0000313|EMBL:CBL14125.1,
RC   ECO:0000313|Proteomes:UP000008953};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Bernalier A.;
RT   "The genome sequence of Roseburia intestinalis XB6B4.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL14125.1, ECO:0000313|Proteomes:UP000008953}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XB6B4 {ECO:0000313|EMBL:CBL14125.1,
RC   ECO:0000313|Proteomes:UP000008953};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FP929050; CBL14125.1; -; Genomic_DNA.
DR   AlphaFoldDB; D4L3D5; -.
DR   KEGG; rix:RO1_39080; -.
DR   PATRIC; fig|718255.3.peg.1252; -.
DR   HOGENOM; CLU_002707_2_0_9; -.
DR   Proteomes; UP000008953; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008998; F:ribonucleoside-triphosphate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 3.20.70.20; -; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR012833; NrdD.
DR   NCBIfam; TIGR02487; NrdD; 1.
DR   PANTHER; PTHR21075; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR21075:SF0; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   Pfam; PF13597; NRDD; 1.
DR   SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00492};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00492}; Oxidoreductase {ECO:0000313|EMBL:CBL14125.1}.
FT   DOMAIN          1..94
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000259|PROSITE:PS51161"
SQ   SEQUENCE   729 AA;  83492 MW;  4FCBED9395A53BBB CRC64;
     MKIIKRSGME DTFDIKKIES AIRRANNSVI DYEKLTDKQI DEISKNVEVA CENMKRSPSV
     EEIQDMVENQ IMNQRAFNVA RNYITYRYKQ ELVRKSNSTD EQILSLLECN NEEVKQENSN
     KNPTVNSVQR DYMAGEVSKD ITKRFLLPPD IVEAHEQGII HFHDADYFAQ HMHNCCLVNL
     EDMLQNGTVI SETMIDRPKS FSTACNIATQ AIAQIASSQY GGQSISLSHL APFVQVSREK
     YRKQVRTELE AIGVTPTEDK VNKIAEIRVK EEINRGVQMI QYQVITLMTT NGQAPFITVF
     MYLDEVPEGQ LRDDLAAVIE EMLHQRILGV KNEQGVYITP AFPKLIYVLE ADNIREGTKY
     WYLTKLAAEC TAKRMVPDYI SEKIMKKLKD GNCYTCMGCR SFLTVDRTKE NYANAKNYVP
     GKKYYGRFNQ GVVTLNLVDV ACSSGKDMDK FWELLDERLD LCYRALIIRH KRLLGTPSDV
     APILWQNGAL ARLKKGETID KLLYDGYSTI SLGYAGLCEC TRYMKGVSHT EPEGTEFALK
     VMRRLNDACT EWKEKHNIDF SLYGTPLEST TYKFAKCLQK RFGIIPGVTD KNYITNSYHV
     HVTEEISAFD KLKFESQFQE LSPGGAISYV EVPNMQNNLD AVLAVMQYIY DNIMYAELNT
     KSDYCMECGY SGEIKIVNDK DGKLVWECPN CGNRDQNKMS VARRTCGYIG TQFWNQGRTQ
     EIKERVLHL
//