ID   D4M1X1_9FIRM            Unreviewed;       365 AA.
AC   D4M1X1;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:CBL25233.1};
DE            EC=1.3.1.12 {ECO:0000313|EMBL:CBL25233.1};
GN   ORFNames=RTO_04730 {ECO:0000313|EMBL:CBL25233.1};
OS   [Ruminococcus] torques L2-14.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Mediterraneibacter.
OX   NCBI_TaxID=657313 {ECO:0000313|EMBL:CBL25233.1, ECO:0000313|Proteomes:UP000008956};
RN   [1] {ECO:0000313|EMBL:CBL25233.1, ECO:0000313|Proteomes:UP000008956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L2-14 {ECO:0000313|EMBL:CBL25233.1,
RC   ECO:0000313|Proteomes:UP000008956};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT   "The genome sequence of Ruminococcus torques L2-14.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL25233.1, ECO:0000313|Proteomes:UP000008956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L2-14 {ECO:0000313|EMBL:CBL25233.1,
RC   ECO:0000313|Proteomes:UP000008956};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
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DR   EMBL; FP929055; CBL25233.1; -; Genomic_DNA.
DR   AlphaFoldDB; D4M1X1; -.
DR   STRING; 33039.ERS852502_00476; -.
DR   KEGG; rto:RTO_04730; -.
DR   PATRIC; fig|657313.3.peg.156; -.
DR   HOGENOM; CLU_055968_2_1_9; -.
DR   Proteomes; UP000008956; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CBL25233.1}.
FT   DOMAIN          4..291
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   365 AA;  40294 MW;  583FF92BA69EBC5C CRC64;
     MNAKKIGFIG LGLIGGSIAK AIRQYYPDYD IIAFDKNKES LALAIQEGTI HTSCSSIDDN
     FRGCNYIFLC APVTYNAAYL SQLKDLLDEN CILTDVGSVK TSIHEEVIRL GMEANFIGGH
     PMAGSEKSGF MNSKAHLIEN AYYILTPSAK VAEEKVDAYK NFVSSLKALP VILDYHEHDH
     ITGTISHLPH IIASTLVNFV HDTDSKEGMM KALAAGGFKD ITRIASSSPV MWQQICLKNS
     ENISQILGEY IEALSHAKDL VDEGNEPALY ALFENSKDYR NSMPNGSAGP IKKQFALYCD
     IIDETGGIAT IATILASNNI SIKNIGIIHN REFEEGVLRI EFYDEDSANR ASVLLQKYRY
     VIYEV
//