ID D4MY95_ANAHA Unreviewed; 416 AA.
AC D4MY95;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Diaminopimelate decarboxylase {ECO:0000313|EMBL:CBL37590.1};
DE EC=4.1.1.20 {ECO:0000313|EMBL:CBL37590.1};
GN Name=lysA {ECO:0000313|EMBL:CUM71274.1};
GN ORFNames=CL2_05230 {ECO:0000313|EMBL:CBL37590.1}, DO83_08565
GN {ECO:0000313|EMBL:AQP39633.1}, ERS852425_00257
GN {ECO:0000313|EMBL:CUM72719.1}, ERS852475_02621
GN {ECO:0000313|EMBL:CUO67736.1}, ERS852571_00125
GN {ECO:0000313|EMBL:CUM71274.1};
OS Anaerostipes hadrus.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerostipes.
OX NCBI_TaxID=649756 {ECO:0000313|EMBL:CBL37590.1, ECO:0000313|Proteomes:UP000008960};
RN [1] {ECO:0000313|EMBL:CBL37590.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL37590.1,
RC ECO:0000313|Proteomes:UP000008960};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Clostridiales sp. SSC/2.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL37590.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL37590.1,
RC ECO:0000313|Proteomes:UP000008960};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000095553, ECO:0000313|Proteomes:UP000095598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5608868 {ECO:0000313|EMBL:CUM72719.1,
RC ECO:0000313|Proteomes:UP000095598}, 2789STDY5834860
RC {ECO:0000313|EMBL:CUO67736.1, ECO:0000313|Proteomes:UP000095611}, and
RC 2789STDY5834959 {ECO:0000313|EMBL:CUM71274.1,
RC ECO:0000313|Proteomes:UP000095553};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AQP39633.1, ECO:0000313|Proteomes:UP000188159}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BPB5 {ECO:0000313|EMBL:AQP39633.1,
RC ECO:0000313|Proteomes:UP000188159};
RX PubMed=27264309; DOI=10.1038/srep27572;
RA Zhang Q., Wu Y., Wang J., Wu G., Long W., Xue Z., Wang L., Zhang X.,
RA Pang X., Zhao Y., Zhao L., Zhang C.;
RT "Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced
RT colitis by a butyrate-producing bacterium.";
RL Sci. Rep. 6:27572-27572(2016).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR600183-50};
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC {ECO:0000256|RuleBase:RU003737}.
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DR EMBL; CP012098; AQP39633.1; -; Genomic_DNA.
DR EMBL; FP929061; CBL37590.1; -; Genomic_DNA.
DR EMBL; CYXY01000001; CUM71274.1; -; Genomic_DNA.
DR EMBL; CYXT01000001; CUM72719.1; -; Genomic_DNA.
DR EMBL; CYZM01000012; CUO67736.1; -; Genomic_DNA.
DR RefSeq; WP_008392203.1; NZ_WQRB01000043.1.
DR AlphaFoldDB; D4MY95; -.
DR STRING; 649756.ERS852387_00341; -.
DR GeneID; 15230681; -.
DR KEGG; bprl:CL2_05230; -.
DR PATRIC; fig|245018.3.peg.706; -.
DR Proteomes; UP000008960; Chromosome.
DR Proteomes; UP000095553; Unassembled WGS sequence.
DR Proteomes; UP000095598; Unassembled WGS sequence.
DR Proteomes; UP000095611; Unassembled WGS sequence.
DR Proteomes; UP000188159; Chromosome.
DR GO; GO:0008836; F:diaminopimelate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro.
DR CDD; cd06828; PLPDE_III_DapDC; 1.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR InterPro; IPR002986; DAP_deCOOHase_LysA.
DR InterPro; IPR022643; De-COase2_C.
DR InterPro; IPR022644; De-COase2_N.
DR InterPro; IPR000183; Orn/DAP/Arg_de-COase.
DR InterPro; IPR029066; PLP-binding_barrel.
DR PANTHER; PTHR43727; DIAMINOPIMELATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43727:SF2; DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF02784; Orn_Arg_deC_N; 1.
DR Pfam; PF00278; Orn_DAP_Arg_deC; 1.
DR PRINTS; PR01181; DAPDCRBXLASE.
DR PRINTS; PR01179; ODADCRBXLASE.
DR SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:CBL37590.1};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR600183-50}.
FT DOMAIN 47..278
FT /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02784"
FT DOMAIN 280..368
FT /note="Orn/DAP/Arg decarboxylase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00278"
FT ACT_SITE 341
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
FT MOD_RES 55
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
SQ SEQUENCE 416 AA; 46245 MW; D560AADAE4C0535F CRC64;
MAKVPFVTKE QLDEIVKKYP TPFHLYDEKG IRETARGLYK AFSWNKGFKE YFAVKATPNP
TILKILKEEG CGTDCSSLTE LMMSDRCGFD GSEIMFSSND TPAEEFILAK QLGATINLDD
ITHIEFLKEC AGIPEKISCR YNPGGVFALG TDIMDNPGDA KYGMTTEQIF EAFKQLKELG
VKEFGIHSFL ASNTVTNEYY PTLAKQLFEL AVKLKEEVGV HIGFINLSGG VGIPYLPDQE
GNDIAVIGEG VHKVYDEVLV PAGMGDVKIF TELGRYMLAP NGHLVTKAIH EKHTHKEYIG
VDACAVNLMR PAMYGAYHHI TVMGKENEPA DHVYDITGSL CENNDKFAID RKLPKIDMGD
LLVIHDTGAH GFAMGYNYNG KLKSAEILLK EDGTTEMIRR AETPEDYFAT IKGFNF
//
