ID D4N1G0_ANAHA Unreviewed; 590 AA.
AC D4N1G0;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Metallopeptidase {ECO:0000313|EMBL:AQP38534.1};
DE SubName: Full=Xaa-Pro aminopeptidase {ECO:0000313|EMBL:CBL38705.1};
DE EC=3.4.11.9 {ECO:0000313|EMBL:CBL38705.1};
GN ORFNames=CL2_17960 {ECO:0000313|EMBL:CBL38705.1}, DO83_02135
GN {ECO:0000313|EMBL:AQP38534.1}, ERS852425_01751
GN {ECO:0000313|EMBL:CUM96677.1}, ERS852520_02400
GN {ECO:0000313|EMBL:CUP86740.1}, ERS852571_01591
GN {ECO:0000313|EMBL:CUM95127.1};
OS Anaerostipes hadrus.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerostipes.
OX NCBI_TaxID=649756 {ECO:0000313|EMBL:CBL38705.1, ECO:0000313|Proteomes:UP000008960};
RN [1] {ECO:0000313|EMBL:CBL38705.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL38705.1,
RC ECO:0000313|Proteomes:UP000008960};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Clostridiales sp. SSC/2.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL38705.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL38705.1,
RC ECO:0000313|Proteomes:UP000008960};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000095553, ECO:0000313|Proteomes:UP000095564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5608868 {ECO:0000313|EMBL:CUM96677.1,
RC ECO:0000313|Proteomes:UP000095598}, 2789STDY5834908
RC {ECO:0000313|EMBL:CUP86740.1, ECO:0000313|Proteomes:UP000095564}, and
RC 2789STDY5834959 {ECO:0000313|EMBL:CUM95127.1,
RC ECO:0000313|Proteomes:UP000095553};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AQP38534.1, ECO:0000313|Proteomes:UP000188159}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BPB5 {ECO:0000313|EMBL:AQP38534.1,
RC ECO:0000313|Proteomes:UP000188159};
RX PubMed=27264309; DOI=10.1038/srep27572;
RA Zhang Q., Wu Y., Wang J., Wu G., Long W., Xue Z., Wang L., Zhang X.,
RA Pang X., Zhao Y., Zhao L., Zhang C.;
RT "Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced
RT colitis by a butyrate-producing bacterium.";
RL Sci. Rep. 6:27572-27572(2016).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; CP012098; AQP38534.1; -; Genomic_DNA.
DR EMBL; FP929061; CBL38705.1; -; Genomic_DNA.
DR EMBL; CYXY01000008; CUM95127.1; -; Genomic_DNA.
DR EMBL; CYXT01000012; CUM96677.1; -; Genomic_DNA.
DR EMBL; CZAU01000025; CUP86740.1; -; Genomic_DNA.
DR RefSeq; WP_009264442.1; NZ_WQRA01000074.1.
DR AlphaFoldDB; D4N1G0; -.
DR STRING; 649756.ERS852387_01521; -.
DR GeneID; 15231796; -.
DR KEGG; bprl:CL2_17960; -.
DR PATRIC; fig|245018.3.peg.2086; -.
DR OrthoDB; 9806388at2; -.
DR Proteomes; UP000008960; Chromosome.
DR Proteomes; UP000095553; Unassembled WGS sequence.
DR Proteomes; UP000095564; Unassembled WGS sequence.
DR Proteomes; UP000095598; Unassembled WGS sequence.
DR Proteomes; UP000188159; Chromosome.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 2.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:CBL38705.1};
KW Hydrolase {ECO:0000313|EMBL:CBL38705.1};
KW Protease {ECO:0000313|EMBL:CBL38705.1}.
FT DOMAIN 7..126
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 307..523
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 533..589
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 590 AA; 67716 MW; 1BCFCAD93C8C5430 CRC64;
MNLNFMKLRE QMENQKVSYY LVPSEDPHQS EYVDDYFKCR QYISGFTGSA GTFLAGCEEG
WLWTDGRYFT QAEGQISSDI TLMKQGVSGV PTILEFLKEH LQEGDTLGVN GFTISASYGK
KIAKLVKQHG ASFRFDLRFV EELWAKDDRP AITKSTIYRH DIKYSGEHTD SKLARVREKM
KELDANAFFL SSLPDIAWLF NLRGDDIACT PLFYSYAWIT IDKCFLFLRK DCISAVAFQR
FKEHGISILD YTEVSAFLKD QHETVLLNPD LTNYLHYNLL FKCKIIEDKN PTELMKAIKN
DIQIDHLKAC HINDGIAMTK FMYWLKKNVG KIPMTERMIS DHLEEERKKL PDYMGPSFET
ICAYKDHAAM MHYQSTEESD VDVKAEGMLL IDSGGQYYGG TTDVTRTFIL GPISEEERKY
FTLVLKSMLT LANAKFLFGC RGSNLDILAR EPLWEDGVDY RCGTGHGVGY FLGVHEGPNA
FRWRSNPENL DAVLQPGMVI TDEPGVYVPG KYGIRTENML ICKKWQQNEY GAFLHFEPLT
LVPIDLDGVD LSLFNEKEKQ LLTDYQQFVY DTLSPHLNEE ESAWLHTLTL
//
