ID D5BYV0_NITHN Unreviewed; 291 AA.
AC D5BYV0;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Nhal_0990 {ECO:0000313|EMBL:ADE14163.1};
OS Nitrosococcus halophilus (strain Nc4).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Nitrosococcus.
OX NCBI_TaxID=472759 {ECO:0000313|EMBL:ADE14163.1, ECO:0000313|Proteomes:UP000001844};
RN [1] {ECO:0000313|Proteomes:UP000001844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nc4 {ECO:0000313|Proteomes:UP000001844};
RG US DOE Joint Genome Institute;
RA Campbell M.A., Malfatti S.A., Chain P.S.G., Heidelberg J.F., Ward B.B.,
RA Klotz M.G.;
RT "Complete genome sequence of Nitrosococcus halophilus Nc4, a salt-adapted,
RT aerobic obligate ammonia-oxidizing sulfur purple bacterium.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP001798; ADE14163.1; -; Genomic_DNA.
DR RefSeq; WP_013032055.1; NC_013960.1.
DR AlphaFoldDB; D5BYV0; -.
DR STRING; 472759.Nhal_0990; -.
DR REBASE; 25085; M.NhaNc4ORF990P.
DR KEGG; nhl:Nhal_0990; -.
DR eggNOG; COG0338; Bacteria.
DR HOGENOM; CLU_063430_4_0_6; -.
DR OrthoDB; 9805629at2; -.
DR Proteomes; UP000001844; Chromosome.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR012263; M_m6A_EcoRV.
DR InterPro; IPR012327; MeTrfase_D12.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR30481; DNA ADENINE METHYLASE; 1.
DR PANTHER; PTHR30481:SF2; MODIFICATION METHYLASE; 1.
DR Pfam; PF02086; MethyltransfD12; 1.
DR PIRSF; PIRSF000398; M_m6A_EcoRV; 1.
DR PRINTS; PR00505; D12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:ADE14163.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001844};
KW Transferase {ECO:0000313|EMBL:ADE14163.1}.
SQ SEQUENCE 291 AA; 33860 MW; D1D4EE51A8EB2049 CRC64;
MAEHYSPLRY PGGKAALSSF LIEVMRSNEL IEPHYIEPYA GGGGAALRLL FEGYVESITI
NDADPRISSF WRAVTEYNDH FISLIYDAEL SVREWRRQRK IYEACDCKDK LSLGFATFYL
NRTTRSGIIH NGGPIGGYKQ SGDYKIDARF NRDTLARRIR RIGMYSERIN IYEKDGIELL
KGIGKRVRAS GRLFIYLDPP YYVKGAKLYM NRFSHEDHRL LAQYLELQAQ FPWIMTYDDV
ESIRHLYSSM RQKEFYLSYS AYKRRRGKEI LIYPDTLEIS DKATSALPMA V
//
