ID D5C358_NITHN Unreviewed; 561 AA.
AC D5C358;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:ADE14950.1};
GN OrderedLocusNames=Nhal_1829 {ECO:0000313|EMBL:ADE14950.1}, Nhal_1848
GN {ECO:0000313|EMBL:ADE14966.1};
OS Nitrosococcus halophilus (strain Nc4).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Nitrosococcus.
OX NCBI_TaxID=472759 {ECO:0000313|EMBL:ADE14950.1, ECO:0000313|Proteomes:UP000001844};
RN [1] {ECO:0000313|EMBL:ADE14950.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nc 4 {ECO:0000313|EMBL:ADE14950.1};
RG US DOE Joint Genome Institute;
RA Campbell M.A., Malfatti S.A., Chain P.S.G., Heidelberg J.F., Ward N.L.,
RA Ward B.B., Klotz M.G.;
RT "Complete genome sequence of Nitrosococcus halophilus Nc4, a salt-adapted,
RT aerobic obligate ammonia-oxidizing sulfur purple bacterium.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000001844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nc4 {ECO:0000313|Proteomes:UP000001844};
RG US DOE Joint Genome Institute;
RA Campbell M.A., Malfatti S.A., Chain P.S.G., Heidelberg J.F., Ward B.B.,
RA Klotz M.G.;
RT "Complete genome sequence of Nitrosococcus halophilus Nc4, a salt-adapted,
RT aerobic obligate ammonia-oxidizing sulfur purple bacterium.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; CP001798; ADE14950.1; -; Genomic_DNA.
DR EMBL; CP001798; ADE14966.1; -; Genomic_DNA.
DR RefSeq; WP_013032835.1; NC_013960.1.
DR AlphaFoldDB; D5C358; -.
DR STRING; 472759.Nhal_1829; -.
DR KEGG; nhl:Nhal_1829; -.
DR KEGG; nhl:Nhal_1848; -.
DR eggNOG; COG1226; Bacteria.
DR eggNOG; COG4651; Bacteria.
DR HOGENOM; CLU_005126_9_0_6; -.
DR OrthoDB; 3418949at2; -.
DR Proteomes; UP000001844; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001844};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 413..535
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 561 AA; 59730 MW; B6C47B6E6F6A0721 CRC64;
MVPFENVFYE IGALLGVAAA GGVLAILLRQ PLIVAFIAVG IIVGPTGFGW VVASDQVDLL
AKLGIALLLF VVGLKLDPHI IRTMGPVALA TGLGQVVFTS VVGYLIALAL GMAPVSALYV
AVALTFSSTI IIVKLLSDKR EVDSLHGRIA IGFLIVQDIM VVLVMIGLTA FGQAGDALSL
GREALLVLAK GAAMLAVVGL LMRYVLPPSL HRLARSPELL VLFSIAWAIL GASAGDTLGF
SKEVGAFLAG VSIAATPYRE LVAARLVSLR DFLLLFFFID LGASLNISTL GAHLEASAVL
SLFVLIGNPF IVMAIMGAMG YRKRTGFLAG LTVAQISEFS LILGALGLNL GHIDQETMGL
ITLVGLITIS LSTYMILYSH PLYERLAPWL GMFERKVAHR EEGVAAAING DTYAFLFGLG
RFGAGIAQIL QKRGCRVLAV DFDPDLVRRH AGEGYMTRYG DAEDPEFVAS LPLERVPWVV
STVRERSVNR TLLHTLRQQG FRGRVAVAAN GQHEAELFRR EGADLVLVPY FDAAREAVDH
LLELGAVGSH PGDSPKESTG A
//
