ID D5E715_METMS Unreviewed; 151 AA.
AC D5E715;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=siroheme decarboxylase {ECO:0000256|ARBA:ARBA00023471};
DE EC=4.1.1.111 {ECO:0000256|ARBA:ARBA00023471};
GN OrderedLocusNames=Mmah_1455 {ECO:0000313|EMBL:ADE36953.1};
OS Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE36953.1, ECO:0000313|Proteomes:UP000001059};
RN [1] {ECO:0000313|EMBL:ADE36953.1, ECO:0000313|Proteomes:UP000001059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35705 / DSM 5219 / SLP
RC {ECO:0000313|Proteomes:UP000001059};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanohalophilus mahii DSM 5219.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2;
CC Xref=Rhea:RHEA:19093, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:60052, ChEBI:CHEBI:140497; EC=4.1.1.111;
CC Evidence={ECO:0000256|ARBA:ARBA00023409};
CC -!- PATHWAY: Porphyrin-containing compound metabolism.
CC {ECO:0000256|ARBA:ARBA00023444}.
CC -!- SIMILARITY: Belongs to the Ahb/Nir family.
CC {ECO:0000256|ARBA:ARBA00023457}.
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DR EMBL; CP001994; ADE36953.1; -; Genomic_DNA.
DR RefSeq; WP_013037895.1; NC_014002.1.
DR AlphaFoldDB; D5E715; -.
DR STRING; 547558.Mmah_1455; -.
DR GeneID; 8983628; -.
DR KEGG; mmh:Mmah_1455; -.
DR HOGENOM; CLU_112007_1_0_2; -.
DR OrthoDB; 145939at2157; -.
DR Proteomes; UP000001059; Chromosome.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 3.30.70.3460; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR040523; AsnC_trans_reg2.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43413:SF1; SIROHEME DECARBOXYLASE NIRL SUBUNIT; 1.
DR PANTHER; PTHR43413; TRANSCRIPTIONAL REGULATOR, ASNC FAMILY; 1.
DR Pfam; PF17805; AsnC_trans_reg2; 1.
DR Pfam; PF13404; HTH_AsnC-type; 1.
DR SMART; SM00344; HTH_ASNC; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000001059}.
FT DOMAIN 4..47
FT /note="HTH asnC-type"
FT /evidence="ECO:0000259|Pfam:PF13404"
FT DOMAIN 64..143
FT /note="Siroheme decarboxylase AsnC-like ligand binding"
FT /evidence="ECO:0000259|Pfam:PF17805"
SQ SEQUENCE 151 AA; 17259 MW; BA79B9AEBFB516B0 CRC64;
MIDLDETDKR ILNEIQLGFP LSIHPYAALA ERLGIPEEEL LKRLERLNRQ GAVRRIGPVI
NTRKAGGTST LIALKAPDSR IHEIGEIISR HPEVSHNYLR PAEYNIWFTI SAADRERLDT
IIKQIVDETD CPILDLPTKR LFKIGVKFDV R
//
