ID D5E7L2_METMS Unreviewed; 697 AA.
AC D5E7L2;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=acetate--CoA ligase (ADP-forming) {ECO:0000256|ARBA:ARBA00012957};
DE EC=6.2.1.13 {ECO:0000256|ARBA:ARBA00012957};
GN OrderedLocusNames=Mmah_1654 {ECO:0000313|EMBL:ADE37150.1};
OS Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE37150.1, ECO:0000313|Proteomes:UP000001059};
RN [1] {ECO:0000313|EMBL:ADE37150.1, ECO:0000313|Proteomes:UP000001059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35705 / DSM 5219 / SLP
RC {ECO:0000313|Proteomes:UP000001059};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanohalophilus mahii DSM 5219.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + ADP + phosphate;
CC Xref=Rhea:RHEA:15081, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456216; EC=6.2.1.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001619};
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DR EMBL; CP001994; ADE37150.1; -; Genomic_DNA.
DR RefSeq; WP_013038092.1; NC_014002.1.
DR AlphaFoldDB; D5E7L2; -.
DR STRING; 547558.Mmah_1654; -.
DR GeneID; 8983834; -.
DR KEGG; mmh:Mmah_1654; -.
DR HOGENOM; CLU_007415_3_1_2; -.
DR OrthoDB; 18103at2157; -.
DR Proteomes; UP000001059; Chromosome.
DR GO; GO:0043758; F:acetate-CoA ligase (ADP-forming) activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.261; Succinyl-CoA synthetase domains; 2.
DR InterPro; IPR014089; AcCoA-synth-alpha.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR043938; Ligase_CoA_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032875; Succ_CoA_lig_flav_dom.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR NCBIfam; TIGR02717; AcCoA-syn-alpha; 1.
DR PANTHER; PTHR43334; ACETATE--COA LIGASE [ADP-FORMING]; 1.
DR PANTHER; PTHR43334:SF1; ACETATE--COA LIGASE [ADP-FORMING]; 1.
DR Pfam; PF13549; ATP-grasp_5; 1.
DR Pfam; PF13380; CoA_binding_2; 1.
DR Pfam; PF19045; Ligase_CoA_2; 1.
DR Pfam; PF13607; Succ_CoA_lig; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52210; Succinyl-CoA synthetase domains; 2.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Reference proteome {ECO:0000313|Proteomes:UP000001059}.
FT DOMAIN 486..522
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 697 AA; 75031 MW; 8EF63493B116739E CRC64;
MLSSLFNPKS VAVIGASNKK GKVGNAVLSN LIKDFGGNIY PVNPRNEEIE GLECYASIND
VSDDVDLAVV VIPAKIVPST LEECGRAGVK YVVVISAGFK EAGVEGAKLE RSALEICRKH
DMRMVGPNCL GIMDPVAGLN ASFAASMAYE GNIAMMSQSG AICTSTLDWA EANGMGFSKF
VSLGNKADLG ENQFLAEFRD DPSTSVIAAY LEGIKNGSQF IEIARDVSRK KPVVLVKSGR
TAAGSRAVSS HTGTLAGSDQ AYNAAFDKAG VVRADTLEDM LDYIRAFSTQ PIPAGRRIAI
LTNAGGLGIL TADACYYEGL ELASFSAETI EGLREFLPDA ASFYNPVDVL GDASAKLYGD
ALEIVLKDPN VDGVILLTSP QAMTDVTSIA RIVIQKVEYS DKPVLCSFVG GTRVMEGNFI
LVAGGVPNYI FPERAVASMG ALCDYGKRRN MIFPLPEPVH SDRKMASALL GKAAAKDKKT
LGLESFDLLK AYGIPVVEIG KASSVEEAIE ESERIGYPVV MKVLSPDISH KTDVGGIRLS
LMNKEDVRRA YHTMMSDVRR YMPSARIAGV QLQRMIEGGR EVIIGMNRDV QFGPLLMFGL
GGTYVEILKD VSFRLAPLNE KDAHSMISSI RSYPLLTGVR GEKAYDVDAV ADVLIRVSRL
VEDFPQILEF EINPLMVLPE GDGCFAMDMR LTLKESN
//
