ID D5G5N4_TUBMM Unreviewed; 309 AA.
AC D5G5N4;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=ER membrane protein complex subunit 2 {ECO:0000256|RuleBase:RU367091};
GN ORFNames=GSTUM_00001500001 {ECO:0000313|EMBL:CAZ79827.1};
OS Tuber melanosporum (strain Mel28) (Perigord black truffle).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Tuberaceae; Tuber.
OX NCBI_TaxID=656061 {ECO:0000313|EMBL:CAZ79827.1, ECO:0000313|Proteomes:UP000006911};
RN [1] {ECO:0000313|EMBL:CAZ79827.1, ECO:0000313|Proteomes:UP000006911}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mel28 {ECO:0000313|EMBL:CAZ79827.1,
RC ECO:0000313|Proteomes:UP000006911};
RX PubMed=20348908; DOI=10.1038/nature08867;
RA Martin F., Kohler A., Murat C., Balestrini R., Coutinho P.M., Jaillon O.,
RA Montanini B., Morin E., Noel B., Percudani R., Porcel B., Rubini A.,
RA Amicucci A., Amselem J., Anthouard V., Arcioni S., Artiguenave F.,
RA Aury J.M., Ballario P., Bolchi A., Brenna A., Brun A., Buee M.,
RA Cantarel B., Chevalier G., Couloux A., Da Silva C., Denoeud F.,
RA Duplessis S., Ghignone S., Hilselberger B., Iotti M., Marcais B., Mello A.,
RA Miranda M., Pacioni G., Quesneville H., Riccioni C., Ruotolo R.,
RA Splivallo R., Stocchi V., Tisserant E., Viscomi A.R., Zambonelli A.,
RA Zampieri E., Henrissat B., Lebrun M.H., Paolocci F., Bonfante P.,
RA Ottonello S., Wincker P.;
RT "Perigord black truffle genome uncovers evolutionary origins and mechanisms
RT of symbiosis.";
RL Nature 464:1033-1038(2010).
CC -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC (EMC) that enables the energy-independent insertion into endoplasmic
CC reticulum membranes of newly synthesized membrane proteins.
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU367091}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU367091}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SIMILARITY: Belongs to the EMC2 family.
CC {ECO:0000256|RuleBase:RU367091}.
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DR EMBL; FN430000; CAZ79827.1; -; Genomic_DNA.
DR RefSeq; XP_002835670.1; XM_002835624.1.
DR AlphaFoldDB; D5G5N4; -.
DR STRING; 656061.D5G5N4; -.
DR EnsemblFungi; CAZ79827; CAZ79827; GSTUM_00001500001.
DR GeneID; 9187504; -.
DR KEGG; tml:GSTUM_00001500001; -.
DR eggNOG; KOG3060; Eukaryota.
DR HOGENOM; CLU_052388_0_0_1; -.
DR InParanoid; D5G5N4; -.
DR OMA; LMEMLFY; -.
DR OrthoDB; 1425339at2759; -.
DR Proteomes; UP000006911; Unassembled WGS sequence.
DR GO; GO:0072546; C:EMC complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR039856; EMC2-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12760:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR12760; TETRATRICOPEPTIDE REPEAT PROTEIN; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU367091};
KW Membrane {ECO:0000256|RuleBase:RU367091};
KW Reference proteome {ECO:0000313|Proteomes:UP000006911};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 155..188
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 309 AA; 34778 MW; A274641EB35E7E06 CRC64;
MAMLKLLLSY LSIHPSPLRN PSTSLHLSQQ APAFLSSSES TKDTQETWLI YEQLLLSCLR
TGDDSSARVC LQRLSGRFGV DSARVKALTG LYDEATSNSR GELESVLQRY QDILKEDPTN
MPIEKRRISL LLSLGRTEDG IEALTSLLSH SPNDAESWAH LSSLYFTQGL YQQSVFCLEE
VLLILPNAYN IFARIGEVTY ISASAGASGT NQTEAFEEAI KYFARSVELS EWYLRGWYGL
KLVTGKFIQA KPSDGTLRKM ESLNQLATEK LLQIVGRFRR NEKGWMGFDE AEILAAKNLI
DRDEQKFSR
//
