ID D5I7E2_PLAVI Unreviewed; 1729 AA.
AC D5I7E2;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Merozoite surface protein 1 {ECO:0000256|ARBA:ARBA00022062};
DE AltName: Full=Merozoite surface antigen {ECO:0000256|ARBA:ARBA00031689};
DE AltName: Full=PMMSA {ECO:0000256|ARBA:ARBA00032276};
DE Flags: Fragment;
GN Name=msp-1 {ECO:0000313|EMBL:ADF48637.1};
OS Plasmodium vivax (malaria parasite P. vivax).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5855 {ECO:0000313|EMBL:ADF48637.1};
RN [1] {ECO:0000313|EMBL:ADF48637.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CMC245 {ECO:0000313|EMBL:ADF48637.1};
RX PubMed=20199765; DOI=10.1016/j.vaccine.2010.02.062;
RA Jongwutiwes S., Putaporntip C., Hughes A.L.;
RT "Bottleneck effects on vaccine-candidate antigen diversity of malaria
RT parasites in Thailand.";
RL Vaccine 28:3112-3117(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
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DR EMBL; GQ891026; ADF48637.1; -; Genomic_DNA.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR PANTHER; PTHR48125; LP07818P1; 1.
DR PANTHER; PTHR48125:SF10; RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG; 1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:ADF48637.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1729
FT /note="Merozoite surface protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003073277"
FT TRANSMEM 1700..1725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 980..1554
FT /note="Merozoite surface 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07462"
FT DOMAIN 1624..1660
FT /note="Merozoite surface protein EGF"
FT /evidence="ECO:0000259|Pfam:PF12946"
FT REGION 209..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1267..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 342..369
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1069..1135
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1467..1538
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 763..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1729
FT /evidence="ECO:0000313|EMBL:ADF48637.1"
SQ SEQUENCE 1729 AA; 194578 MW; FB76F094C06C8654 CRC64;
MKALLFLFSF IFFVTKCQCE TESYKQLVAK LDKLEALVVD GYELFHKKKL GENDIKVETN
ASANNNNNNQ VSVLTSKIRN FLSKFLELQI PGHTDLLHLI RELAVEPNGI KYLVESYEEF
NQLMHVINFH YDLLRAKLHD MCAHDYCKIP EHLKISDKEL DMLKKVVLGY RKPLDNIKDD
IGKLEAFITK NKETISNINK LISDENAKRG GQSISTISGN GAQTDGHQPT TASSETSSGS
SVSSVSGSSG LGSSGTGSTG NRSPSQAPAA PSSTNANYEA KKIIFQAIYN GIFYTNQLEE
AQKLIAVLEK RVKVLKEHKD IKVLLEQVAK EKEKLPNDYP NTTNLTNVHK EAESKIAELE
KKIEAIAKTV NFDLDGLFTD AEELEYYLRE KAKMAGTLII PESTKSAGTP GKTVPTLKET
YPHGISYALA ENSIYELIEK IGSDETFGDL QNPDDGKQPK KGILINETKR KELLEKIMNK
IKIEEDKLPN LKKEYEEKYK VYEAKVNEFK PAFNHFYEAR LDNTLVENKF DEFKTKREAY
MEEKKKLESC SYEQNTNLIN KLKKQLTYLE DYVLRKDIAD NEIKHFSFME WKLKSEIYDL
AQEIRKNENK LTVENKFDFS GVVELQVQKV LIIKKIEALK NVQNLLKNAK VKDDLYIPKV
YKTGEKPEPY YLMVLKREID KLKDFIPKIE SMIATEKNKP TVAAADIVAK GQSLRGASET
GTTGNTVNAQ TAVVQQPQQQ QQQQQQQQQQ QQQQQQQQQQ QQSQVVPAPA GDAQQVISTQ
PTSQSAAPGV SATPAPTPAA AAAPAPAMSK LEYLEKLLDF LKSAYACHKH IFVTNSTMDK
KLLKEYELNA DEKTKINQNK CDELDLLFNV QNNLPAMYSI YDSMSSELQN LYIELYQKEM
VYNIYKNKDT DKKIKAFLET SNNKAAAPAQ SAAKPSGQAG TTPVTTTAPV TTTTVTPSPQ
TSVVTSTPPT PQAEENQRVG GNSEEKPEAD TAQVEKFYEK HLSQIDKYND YFKKFLESKK
EEIIKMDDTK WNALGKEIEE LKKKLQVSLD HYGKYKLKLE RFLKKKNKIS NSKDQIKKLT
SLKNKLERRQ NLLNNPTSVL KNYTAFFNKK RETEKKEVEN TLKNTEILLK YYKARAKYYI
GEPFPLKTLS EESLQKEDNY LNLEKFRVLS RLEGRLGKNI ELEKENISYL SSGLHHVLTE
LKEIIKNKKY SGNDHTKNIA AVKEALQAYQ ELIPKVTTQE GASTTAATLP VTVPSAVPGG
LPGAGVPGAA AGLTPPPPAG SVPATGPGAA AGSTEENVAA KAQDYAEDYD KVIALPLFGN
NDDDGEEDQV TTGEAESEAP EILVPAGISD YDVVYLKPLA GMYKTIKKQL ENHVNAFNTN
ITDMLDSRLK KRNYFLEVLN SDLNPFKYSS SGEYIIKDPY KLLDLEKKKK LIGSYKYIGA
SIDMDVATAN DGVAYYNKMK ELYKTHLTAV NEEVKKVEAD IKAEDDKIKK IENEANKAAE
KTQSMAKKAE LEKYLPFLNS LQKEYESLVS KVNTYTDNLK KVISNCQLEK KEAEITVKKL
QDYNKMDEKL EEYKKSEKKN EVKSSGLLEK LMKSKLIKEN ESKEILSQLL NVQTQLLTMS
SEHTCIDTNV PDNAACYRYL DGTEEWRCLL TFKEEGGKCV PASNVTCKDN NGGCAPEAEC
KMTDSNKIVC KCTKEGSEPL FEGVFCSSSS FLSLSFLLLM LLFLLCMEL
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