ID D5JA89_TRYCR Unreviewed; 263 AA.
AC D5JA89;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=MSH2 {ECO:0000313|EMBL:ADF30336.1};
DE Flags: Fragment;
GN Name=MSH2 {ECO:0000313|EMBL:ADF30336.1};
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693 {ECO:0000313|EMBL:ADF30336.1};
RN [1] {ECO:0000313|EMBL:ADF30336.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TC California {ECO:0000313|EMBL:ADF30336.1};
RX PubMed=23457528;
RA Roellig D.M., Savage M.Y., Fujita A.W., Barnabe C., Tibayrenc M.,
RA Steurer F.J., Yabsley M.J.;
RT "Genetic Variation and Exchange in Trypanosoma cruzi Isolates from the
RT United States.";
RL PLoS ONE 8:E56198-E56198(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GU212988; ADF30336.1; -; Genomic_DNA.
DR AlphaFoldDB; D5JA89; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_007031; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 173..263
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADF30336.1"
FT NON_TER 263
FT /evidence="ECO:0000313|EMBL:ADF30336.1"
SQ SEQUENCE 263 AA; 29419 MW; 5298CE76ED78DED6 CRC64;
EHQRLMKVYG WTEKQLKCEY HTTYGYVFRV TRKEDQQVRT SKELITVSTS KDGVRFVSER
LSSLSEQYKG IRKVYDVRQQ DLKQKLVSTV VTYLPVLDDA KELIAALDVF VAWATVVRDS
PHPMVRPTIR TPETEEEQEG NKSLITLINV RHPLVELRQP VYTPNTLRLT DDANALIITG
PNMGGKSTFM RSVGISVVLA QAGCFVPADS ADMVTRDAVM CRVGATDHLA QGVSTFMVEM
LESAAILNAA TRDSLAVIDE LGR
//
