ID D5K539_HELPX Unreviewed; 152 AA.
AC D5K539;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 13-SEP-2023, entry version 44.
DE RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
DE Flags: Fragment;
GN Name=trpC {ECO:0000313|EMBL:ADE42094.1};
OS Helicobacter pylori (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=210 {ECO:0000313|EMBL:ADE42094.1};
RN [1] {ECO:0000313|EMBL:ADE42094.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SLN052 {ECO:0000313|EMBL:ADE42094.1};
RX PubMed=20339588; DOI=10.1371/journal.pone.0009645;
RA Latifi-Navid S., Ghorashi S.A., Siavoshi F., Linz B., Massarrat S.,
RA Khegay T., Salmanian A.H., Shayesteh A.A., Masoodi M., Ghanadi K.,
RA Ganji A., Suerbaum S., Achtman M., Malekzadeh R., Falush D.;
RT "Ethnic and geographic differentiation of Helicobacter pylori within
RT Iran.";
RL PLoS ONE 5:E9645-E9645(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001633};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
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DR EMBL; GU444926; ADE42094.1; -; Genomic_DNA.
DR AlphaFoldDB; D5K539; -.
DR UniPathway; UPA00035; UER00043.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Isomerase {ECO:0000313|EMBL:ADE42094.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 1..152
FT /note="Indole-3-glycerol phosphate synthase"
FT /evidence="ECO:0000259|Pfam:PF00218"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADE42094.1"
FT NON_TER 152
FT /evidence="ECO:0000313|EMBL:ADE42094.1"
SQ SEQUENCE 152 AA; 17021 MW; 15B5A407277D0996 CRC64;
CISVLADSKY FLGSYENIKI VSQRSNKPIL CKDFIIDAFQ IKLARVMGAN AVLLMLSALD
DKNYLELFNL AKSLNMSVLT EVSNKQEIKR LLKLQYDIIG INNRDLHTLT TDINNTLKLR
SLLPKDALVV SESGIHSHAQ IKALAPYVNG FL
//
