ID D5K565_HELPX Unreviewed; 152 AA.
AC D5K565;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 13-SEP-2023, entry version 46.
DE RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
DE Flags: Fragment;
GN Name=trpC {ECO:0000313|EMBL:ADE42120.1};
OS Helicobacter pylori (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=210 {ECO:0000313|EMBL:ADE42120.1};
RN [1] {ECO:0000313|EMBL:ADE42120.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SLN078 {ECO:0000313|EMBL:ADE42120.1}, and SLN142
RC {ECO:0000313|EMBL:ADE42183.1};
RX PubMed=20339588; DOI=10.1371/journal.pone.0009645;
RA Latifi-Navid S., Ghorashi S.A., Siavoshi F., Linz B., Massarrat S.,
RA Khegay T., Salmanian A.H., Shayesteh A.A., Masoodi M., Ghanadi K.,
RA Ganji A., Suerbaum S., Achtman M., Malekzadeh R., Falush D.;
RT "Ethnic and geographic differentiation of Helicobacter pylori within
RT Iran.";
RL PLoS ONE 5:E9645-E9645(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001633};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GU444952; ADE42120.1; -; Genomic_DNA.
DR EMBL; GU445015; ADE42183.1; -; Genomic_DNA.
DR AlphaFoldDB; D5K565; -.
DR UniPathway; UPA00035; UER00043.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Isomerase {ECO:0000313|EMBL:ADE42120.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 1..152
FT /note="Indole-3-glycerol phosphate synthase"
FT /evidence="ECO:0000259|Pfam:PF00218"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADE42120.1"
FT NON_TER 152
FT /evidence="ECO:0000313|EMBL:ADE42120.1"
SQ SEQUENCE 152 AA; 17052 MW; 5EA88F769348EA56 CRC64;
CISVLADSKY FLGSYENIKI VSQHSTKPIL CKDFIIDAFQ IKLARVMGAN AVLLMLSVLD
DKNYLELFNL AKSLNMSVLT EVSNQQEIER LLKLQYDIIG INNRDLHTLT TDINHTLELR
PLLPKDALVV SESGIHSHAQ IKALAPYVNG FL
//
