ID D5KAV3_9PEZI Unreviewed; 399 AA.
AC D5KAV3;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Elongation factor 1-alpha {ECO:0000256|ARBA:ARBA00013870, ECO:0000256|RuleBase:RU000325};
DE Flags: Fragment;
GN Name=EF1-a {ECO:0000313|EMBL:ADE35299.1};
OS Morchella brunnea.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Morchellaceae; Morchella.
OX NCBI_TaxID=1174671 {ECO:0000313|EMBL:ADE35299.1};
RN [1] {ECO:0000313|EMBL:ADE35299.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M698 {ECO:0000313|EMBL:ADE35299.1};
RX PubMed=20888422; DOI=10.1016/j.fgb.2010.09.006;
RA O'Donnell K., Rooney A.P., Mills G.L., Kuo M., Weber N.S., Rehner S.A.;
RT "Phylogeny and historical biogeography of true morels (Morchella) reveals
RT an early Cretaceous origin and high continental endemism and provincialism
RT in the Holarctic.";
RL Fungal Genet. Biol. 48:252-265(2011).
RN [2] {ECO:0000313|EMBL:AET52187.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HT431 {ECO:0000313|EMBL:AET52187.1}, and HT839
RC {ECO:0000313|EMBL:AET52199.1};
RX PubMed=22123659; DOI=10.3852/11-180;
RA Taskin H., Buyukalaca S., Hansen K., O'Donnell K.;
RT "Multilocus phylogenetic analysis of true morels (Morchella) reveals high
RT levels of endemics in Turkey relative to other regions of Europe.";
RL Mycologia 104:446-461(2012).
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|RuleBase:RU000325}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249,
CC ECO:0000256|RuleBase:RU000325}.
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DR EMBL; GU551563; ADE35299.1; -; Genomic_DNA.
DR EMBL; JN085093; AET52187.1; -; Genomic_DNA.
DR EMBL; JN085105; AET52199.1; -; Genomic_DNA.
DR AlphaFoldDB; D5KAV3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR NCBIfam; TIGR00483; EF-1_alpha; 1.
DR PANTHER; PTHR23115:SF170; ELONGATION FACTOR 1-ALPHA 2; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:ADE35299.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000325};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000325};
KW Protein biosynthesis {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:ADE35299.1}.
FT DOMAIN 1..210
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADE35299.1"
FT NON_TER 399
FT /evidence="ECO:0000313|EMBL:ADE35299.1"
SQ SEQUENCE 399 AA; 43724 MW; 6D535C463247A7F9 CRC64;
CGGIDKRTIE KFEKEAAELG KGSFKYAWVL DKLKAERERG ITIDIALWKF ETPKYYVTVI
DAPGHRDFIK NMITGTSQAD CAVLIIAAGT GEFEAGISKD GQTREHALLA YTLGVKQLIV
AINKMDTTKW SEDRFKEIVK ETSNFIKKVG YNPKSVAFVP ISGFNGDNMI DSSSNCPWYK
GWERETKAGK SSGKTLLDAI DSIEPPTRPT EKPLRLPLQD VYKIGGIGTV PVGRVETGVI
KPGMVVTFAP AGVTTEVKSV EMHHEQLTEG LPGDNVGFNV KNVSVKEIRR GNVAGDSKND
PPKGAESFNA QVILMNHPGQ VGNGYAPVLD CHTAHIACKF AELLEKIDRR TGKSTETSPK
FIKSGDAAIV KMVPSKPMCV ESFTEYPPLG RFAVRDMRQ
//
