ID D5KJX0_BACPU Unreviewed; 354 AA.
AC D5KJX0;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:ADF50153.1};
OS Bacillus pumilus (Bacillus mesentericus).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1408 {ECO:0000313|EMBL:ADF50153.1};
RN [1] {ECO:0000313|EMBL:ADF50153.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GBSW2 {ECO:0000313|EMBL:ADF50153.1};
RA Xue P.Q., Gao X.W.;
RT "Genotypic and phenotypic analysis of antagonistic Bacillus spp. isolated
RT from rhizosphere soil of plants in Tibet.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
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DR EMBL; GU568234; ADF50153.1; -; Genomic_DNA.
DR AlphaFoldDB; D5KJX0; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 296..354
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADF50153.1"
FT NON_TER 354
FT /evidence="ECO:0000313|EMBL:ADF50153.1"
SQ SEQUENCE 354 AA; 39276 MW; 4EF4BFD59FE65361 CRC64;
ALSTTLDVTV YRDGKIHYQQ FKRGVPAGDL EIIGETDVTG TTTHFVPDPE IFTETIEFDY
DTLANRVREL AFLTKGVNII IEDLREGKER RNEYCYEGGI KSYVEHLNRS KEVVHEEPVY
IEGEKDGITI EVALQYNDSY SSNIYSFANN INTYEGGTHE AGFKTGLTRV INDYARKNGV
FKDGDSNLSG EDVREGLTAI ISIKHPDPQF EGQTKTKLGN SEARTITDSL FSEALEKFLL
ENPDAAKKIV EKGVMAARAR MAAKKARELT RRKSALEVSS LPGKLADCSS KDPSISELYI
VEGDSAGGSA KQGRDRHFQA ILPLRGKILN VEKARLDKIL SNNEVRSMIT ALGT
//
