ID D5P8Y7_9MYCO Unreviewed; 873 AA.
AC D5P8Y7;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Putative formate dehydrogenase, alpha subunit {ECO:0000313|EMBL:EFG77462.1};
DE EC=1.2.1.2 {ECO:0000313|EMBL:EFG77462.1};
GN ORFNames=HMPREF0591_2631 {ECO:0000313|EMBL:EFG77462.1};
OS Mycobacterium parascrofulaceum ATCC BAA-614.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium simiae complex.
OX NCBI_TaxID=525368 {ECO:0000313|EMBL:EFG77462.1, ECO:0000313|Proteomes:UP000003653};
RN [1] {ECO:0000313|EMBL:EFG77462.1, ECO:0000313|Proteomes:UP000003653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-614 {ECO:0000313|EMBL:EFG77462.1,
RC ECO:0000313|Proteomes:UP000003653};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFG77462.1}.
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DR EMBL; ADNV01000215; EFG77462.1; -; Genomic_DNA.
DR AlphaFoldDB; D5P8Y7; -.
DR eggNOG; COG0243; Bacteria.
DR HOGENOM; CLU_000422_1_2_11; -.
DR Proteomes; UP000003653; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 2.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR048158; Formate_DH_Act.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR NCBIfam; NF041513; formate_DH_Act; 1.
DR PANTHER; PTHR43598:SF1; FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT; 1.
DR PANTHER; PTHR43598; TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT B; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EFG77462.1}.
FT DOMAIN 1..384
FT /note="Molybdopterin oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00384"
FT DOMAIN 701..810
FT /note="Molybdopterin dinucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF01568"
FT REGION 111..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 96985 MW; 164EBA8E417051AC CRC64;
MGSNMAEAHP VGFQWVMEAK ANGAEVIHID PRFTRTSAVA DRHVPLRAGS DIAFLGGVIN
YILSNELDFR EYVTAYTNAS FLVDENYRDT EDLDGLFSGY DHETASYDPA SWHYESTHHG
GRGGAAAKQS AAPDQLGSGG AAVEGGAGEI PGDPTLQHPR CVYQILKRHY ARYTPEMVER
VCGVPAETFL QVARAWAENS GRERTAALVY SVGWTQHSMG AQFIRAGSII QLLLGNIGRP
GGGVFALRGH ASIQGSTDVP TLFNLLPGYL AMPHAGQETL ADYLDRVRSQ NQKGFWHNAD
SYMVSLLKEY WGEHATAEND FCFDYLPRIS GDHGTYRTVM DMIDGKVFGY FLLGQNPAVG
SAHGRLQRLG MANLDWLVVR DLVMIESATF WKDSPEIETG EIAPETCRTE VFFFPAAGHV
EKAGTFTQTQ RMLQWREKAV DPPGDARSEL WFFYHLGRKL REKLAGSTDE RDRPLLDLAW
DYATEDAEGD EPSGEDVLRR MNGVDLTSGR AVNGYTELKA DGSTACGCWI YSGVYADEVN
QAARRKPKEE QGPYESEWGW TWPMNRRVLY NRASADPGGR PWSERKKLVW WDPERGEWTG
HDIPDFEKTK PPDYRPPDGA VGVEALRGDD PFVMQADGKA WLFAPNGLAD GPLPTHYEPH
ESPVRNALYA QQGNPTRIVY GRKDNPSNPS PPEAHAEVFP FVFTAARLTE HHTAGGMSRQ
LPYLAELQPA LFVEVSPELA RLRGLTHMDW AHVITSRTAV DARVFVTDRM TPLRIEDRVV
QQVWMPYHWG GAGLVDGDVV NDLLGVVLDP NVFIQESKVA TCDVRPGRRP RGPALLEYVA
DYRRRAGVTA ETGTHIDTTR TDGVGHAEPE EKP
//
