ID D5P929_9MYCO Unreviewed; 436 AA.
AC D5P929;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Cyclopropane-fatty-acyl-phospholipid synthase {ECO:0000313|EMBL:EFG77418.1};
DE EC=2.1.1.79 {ECO:0000313|EMBL:EFG77418.1};
GN Name=cfa {ECO:0000313|EMBL:EFG77418.1};
GN ORFNames=HMPREF0591_2673 {ECO:0000313|EMBL:EFG77418.1};
OS Mycobacterium parascrofulaceum ATCC BAA-614.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium simiae complex.
OX NCBI_TaxID=525368 {ECO:0000313|EMBL:EFG77418.1, ECO:0000313|Proteomes:UP000003653};
RN [1] {ECO:0000313|EMBL:EFG77418.1, ECO:0000313|Proteomes:UP000003653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-614 {ECO:0000313|EMBL:EFG77418.1,
RC ECO:0000313|Proteomes:UP000003653};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the CFA/CMAS family.
CC {ECO:0000256|ARBA:ARBA00010815}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFG77418.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADNV01000220; EFG77418.1; -; Genomic_DNA.
DR AlphaFoldDB; D5P929; -.
DR eggNOG; COG2230; Bacteria.
DR HOGENOM; CLU_026434_6_2_11; -.
DR Proteomes; UP000003653; Unassembled WGS sequence.
DR GO; GO:0008825; F:cyclopropane-fatty-acyl-phospholipid synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003333; CMAS.
DR InterPro; IPR020803; PKS_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43667; CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE; 1.
DR PANTHER; PTHR43667:SF1; CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE; 1.
DR Pfam; PF02353; CMAS; 1.
DR PIRSF; PIRSF003085; CMAS; 1.
DR SMART; SM00828; PKS_MT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Methyltransferase {ECO:0000313|EMBL:EFG77418.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFG77418.1}.
FT DOMAIN 165..429
FT /note="Polyketide synthase methyltransferase"
FT /evidence="ECO:0000259|SMART:SM00828"
SQ SEQUENCE 436 AA; 48578 MW; 1F00141A9FFAFA6F CRC64;
MTTTKEPHRA TAGKLSMAEI LEIFAATGRH PLKFTAYDGS CAGSKDAELG LDLRTPRGAT
YLATAPGELG LARAYVSGDL DLYGVHPGDP YRLLTTLTDR VQFKRPPARV LANVVRSMGL
ERLVPVAPPP QETPPRWRRI ADGLMHTKTR DAEAIHHHYD VSNAFYEWVL GPSMTYTCAV
YPDADATLEE AQENKYRLVF EKLGLQPGDR LLDVGCGWGG MARYAARRGV RVIGATLSAE
QAKWAQRRIE DEGLADLAEV RHSDYRDIRE SGFDAVSSIG LTEHIGVKNY PAYFGFLKSR
LRTGGLLLNH CITRHDNKST SFAGGFTDRY VFPDGELTGS GRIITEVQDV GFEVLHEENF
RHHYAMTLRD WCRNLVAHWD EAVDEVGLAT AKVWGLYMAA SRVAFEQNNL QLHHVLAANV
DARGADHLPL RPWWTP
//
