ID D5T1P5_LEUKI Unreviewed; 344 AA.
AC D5T1P5;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Maltose epimerase {ECO:0000256|PIRNR:PIRNR005096};
DE EC=5.1.3.21 {ECO:0000256|PIRNR:PIRNR005096};
GN OrderedLocusNames=LKI_03260 {ECO:0000313|EMBL:ADG40194.1};
OS Leuconostoc kimchii (strain IMSNU 11154 / KCTC 2386 / IH25).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=762051 {ECO:0000313|EMBL:ADG40194.1, ECO:0000313|Proteomes:UP000002362};
RN [1] {ECO:0000313|EMBL:ADG40194.1, ECO:0000313|Proteomes:UP000002362}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMSNU 11154 / KCTC 2386 / IH25
RC {ECO:0000313|Proteomes:UP000002362};
RX PubMed=20494991; DOI=10.1128/JB.00508-10;
RA Oh H.M., Cho Y.J., Kim B.K., Roe J.H., Kang S.O., Nahm B.H., Jeong G.,
RA Han H.U., Chun J.;
RT "Complete genome sequence analysis of Leuconostoc kimchii IMSNU 11154.";
RL J. Bacteriol. 192:3844-3845(2010).
CC -!- FUNCTION: Catalyzes the interconversion of alpha and beta anomers of
CC maltose. {ECO:0000256|PIRNR:PIRNR005096}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001614};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-maltose = beta-maltose; Xref=Rhea:RHEA:21228,
CC ChEBI:CHEBI:18147, ChEBI:CHEBI:18167; EC=5.1.3.21;
CC Evidence={ECO:0000256|PIRNR:PIRNR005096};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
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DR EMBL; CP001758; ADG40194.1; -; Genomic_DNA.
DR RefSeq; WP_013102790.1; NC_014136.1.
DR AlphaFoldDB; D5T1P5; -.
DR STRING; 762051.LKI_03260; -.
DR KEGG; lki:LKI_03260; -.
DR PATRIC; fig|762051.18.peg.657; -.
DR eggNOG; COG2017; Bacteria.
DR HOGENOM; CLU_031753_1_1_9; -.
DR OrthoDB; 9779408at2; -.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000002362; Chromosome.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0050558; F:maltose epimerase activity; IEA:RHEA.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR018052; Ald1_epimerase_CS.
DR InterPro; IPR015443; Aldose_1-epimerase.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091:SF50; ALDOSE 1-EPIMERASE; 1.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF005096; GALM; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096}.
FT ACT_SITE 174
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT ACT_SITE 310
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT BINDING 174..176
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 246
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ SEQUENCE 344 AA; 38259 MW; E61739CA811A3B58 CRC64;
MKITESSFGG SAKQYTLENN HGVRLSVTNF GARIVRLQVP VAGVYRDLVL GFDSMAEYLD
KDHFMGATIG RVAGRIAAGQ FNLNGKDYQI SINENGNTLH GGPDSFETKI WQVKKQVTDD
LVSVSFTYDS LNHENGFPGN LHVTVTYSLN NDNDWMLTYQ ALSDMSTLFN PTNHVYFNLD
GSPSKSVEDH SLQIIADHYA PLDNDRLTTG KKEHVENSAF DFRKLKKLKE VFTSRNAQNK
LVDGLDHPFF LNAKNDQSSN AKLVSSDEKV SVNLTTSSPA VVIFTANFGN DFSAPMRGTV
FNNHGGITLE TQVAPGAERY PEFGDMICHS DKVYREQTVF ELSF
//
