ID D5XMC2_ZONAL Unreviewed; 1319 AA.
AC D5XMC2;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=G protein-coupled receptor 116 {ECO:0000313|EMBL:ADD70283.1};
GN Name=GPR116 {ECO:0000313|EMBL:ADD70283.1};
OS Zonotrichia albicollis (White-throated sparrow) (Fringilla albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passerellidae; Zonotrichia.
OX NCBI_TaxID=44394 {ECO:0000313|EMBL:ADD70283.1};
RN [1] {ECO:0000313|EMBL:ADD70283.1}
RP NUCLEOTIDE SEQUENCE.
RA Benjamin B., Blakesley R.W., Bouffard G.G., Brooks S., Chodroff R., Chu G.,
RA Chub I., Coleman H., Fuksenko T., Gestole M., Gregory M., Guan X.,
RA Gupta J., Gurson N., Han J., Hansen N., Hargrove A., Hines-Harris K.,
RA Ho S.-L., Hu P., Hurle B., Idol J.R., Johnson T., Kwong P., Lee-Lin S.-Q.,
RA Legaspi R., Lovett S., Madden M., Maduro Q.L., Maduro V.B., Margulies E.H.,
RA Masiello C., Maskeri B., McDowell J., Montemayor C., Mullikin J.C.,
RA Myrick J., Palumbo A., Park M., Prasad A., Ramsahoye C., Reddix-Dugue N.,
RA Riebow N., Schandler K., Schmidt B., Schueler M.G., Sison C., Smith L.,
RA Stantripop S., Thomas J.W., Thomas P.J., Tsipouri V., Young A., Green E.D.;
RT "NISC Comparative Sequencing Initiative.";
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DP001173; ADD70283.1; -; Genomic_DNA.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd00099; IgV; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF4; ADHESION G PROTEIN-COUPLED RECEPTOR F5; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:ADD70283.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 987..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1026..1048
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1068..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1102..1124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1144..1172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1193..1213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1219..1242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..273
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 235..348
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 356..469
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 474..565
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 985..1243
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1296..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1319 AA; 146975 MW; 27C3F324A68D1EF1 CRC64;
MKVMEEDLAG VEKNPSRSEK ELPGRRQELV FILDLPFPEH TFDIEVSLQD SSYLDEIKAY
FKNIDLPINI SNVQTTVSNI SITTVCLPSG ENSSCCFCED GYAWPSTVCS DVMPCPSLSL
EPALPCGYMQ KMPFYGPYCE PQTEESCGMG EPILMNMSVR LDSNFQDDLK NSSSLLYQKY
KMDLEKAFNA SYRCLPGFVS ATVTGFSPGS VFVNFEVRTG AASFTQVGHS NRAVPQFLDS
SYQLNPFTFT RVITNQTNFT VKPSNIFEGD TVRLTCEINS TFSNVTWYHF DQTISAGSRY
SIETDSASTR SILTITNVTM KDSGSYSCVS IRSGPYHTEI HNGTETISVF PLHVTPNFED
IDVTCNSPEV QAKGLQLSCC IDRHMTSLRV SWKVNGTINI IEVFLDIHSP LNNAYCCLGE
TILSGNCTGY QLAINESLCP PEKSGAVTTY TCEMETGHGA RRARSIAVTY LRKAHVTISS
STNSRVSEGY GFNVTCESDV SNYDSISWKI QSGNDTKPVD CGTCIKNSKF PAVSVLTVKS
ASQDWRGTYI CTFSQKNLDS SANITIKVVS LPLKKNILVD PIETSIQCEV PRALECCISA
KTVREYRVTF VVQQNEFPIE ERKKDNLLCY TYNHTEKECN KEKEVMAYCK FVNRIGQGVD
SEHITLHLIP GKKVSCSDSL GIGTEGDILI KPCCDVKNPT GFTRGNITYL CNHSSWIVAR
NDCLSEPINN LLSDAETKKE LTTIKNSSAN LGAIITILDM VSSIPVEAEE PPMQNFLSTV
DLIVDNSTTE AWENLKEEKT RQSSLLLQSV ENFSLRLQPV NNTIPSVSAN TVQLQGVVVK
ENNNTAYNKD FRSAENLTVN VLISETEIQN LTQNSTIVSV MYSKLGHFLP QKTSEFVNGL
LITTTLSSNR SQKFDVNMTF AKKDLSLKMP KCVFWNFTLN NHKGDWDNYG CTPTESERYV
ICSCNHLTSF SILMSPDRSS ELIFENYISY VGLAISIVSL VVCIIIESLV WKYVTNNTTS
YMRHVCILNI ATSLLIADVW FIVIASITDQ NQQMSRDICI MATFFIHFFY LCVFFWMLSL
GLILFYRLVF ILHNTSKTAQ KTVAFCLGYV CPFVIAVTTI AVTLPKNSYT RKDVCWLNWQ
DSKALLAFVI PALIIVATNL FIAAVVIIKI LRPTIGDRSS GQERKSLFQI GKSVAILTPL
LGLTWGFGLA TIIKNSHPAF HILFSLLNAL QGLFIFVFGT LWDKKIQEAL LKRNSSSKWS
SQQSKSSSLI LVTPMLAMSY PFSRTFNNLC GKTGKYRVSS SEPSTSSTEN TSKAYSLLN
//
