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Database: UniProt
Entry: D6IC86_ECOLX
LinkDB: D6IC86_ECOLX
Original site: D6IC86_ECOLX 
ID   D6IC86_ECOLX            Unreviewed;       777 AA.
AC   D6IC86;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   SubName: Full=DNA primase {ECO:0000313|EMBL:EFF05073.2};
GN   ORFNames=ECDG_03496 {ECO:0000313|EMBL:EFF05073.2};
OS   Escherichia coli B185.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=550676 {ECO:0000313|EMBL:EFF05073.2, ECO:0000313|Proteomes:UP000004669};
RN   [1] {ECO:0000313|EMBL:EFF05073.2, ECO:0000313|Proteomes:UP000004669}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B185 {ECO:0000313|EMBL:EFF05073.2,
RC   ECO:0000313|Proteomes:UP000004669};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA   Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Escherichia coli B185.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG749174; EFF05073.2; -; Genomic_DNA.
DR   RefSeq; WP_000783692.1; NZ_GG749174.1.
DR   AlphaFoldDB; D6IC86; -.
DR   Proteomes; UP000004669; Unassembled WGS sequence.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003896; F:DNA primase activity; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd01029; TOPRIM_primases; 1.
DR   Gene3D; 3.40.1360.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR   InterPro; IPR004968; DNA_primase/NTPase_C.
DR   InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR   InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR   InterPro; IPR045455; NrS-1_pol-like_helicase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014818; Phage/plasmid_primase_P4_C.
DR   InterPro; IPR013237; Phage_T7_Gp4_N.
DR   InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR35372; ATP BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR35372:SF2; SF3 HELICASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF08706; D5_N; 1.
DR   Pfam; PF19263; DUF5906; 1.
DR   Pfam; PF03288; Pox_D5; 1.
DR   Pfam; PF08273; Prim_Zn_Ribbon; 1.
DR   Pfam; PF13362; Toprim_3; 1.
DR   SMART; SM00885; D5_N; 1.
DR   SMART; SM00778; Prim_Zn_Ribbon; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR   PROSITE; PS51206; SF3_HELICASE_1; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Primosome {ECO:0000256|ARBA:ARBA00022515};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          208..296
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
FT   DOMAIN          474..627
FT                   /note="SF3 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51206"
SQ   SEQUENCE   777 AA;  84806 MW;  90508E2E5C1264C9 CRC64;
     MKMNVTATVS HALGHWPRIL PALGIQVLKN RHQPCPVCGG SDRFRFDDRE GRGTWYCNQC
     GAGDGLKLVE KVFGVSPSDA ATKVAAVTGS LPPADPAVTA AAVAETEAAR KNAAALAQTL
     MAKTRPGTGN AYLTRKGFPG RECRMLTGTH RAGGVSWRAG DLVVSLYDDS GELVNLQLIS
     ADGRKRTLKG GQVRGTCHTL EGQNQAGKRL WIAEGYATAL TVHHLTGETV MVALSSVNLL
     SLASLARQKH PACQIVLAAD RDLSGDGQKK AAAAADACEG VVALPPVFGD WNDAFTQYGG
     EATRKAIYDA IRPPAESPFD TMSEAEFSAM STSEKAMRIY EHYGEALAVD ANGQLLSRYE
     NGVWKVLPPQ DFARDVAGLF QRLRAPFSSG KVASVVDTLK LIIPQQEAPS RCLIGFRNGV
     LDTQNGTFHP HSPSHWMRTL CDVDFTPPVE GETLETHAPA FWRWLDRAAG GRAEKRDVIL
     AALFMVLANR YDWQLFLEVT GPGGSGKSIM AEIATLLAGE DNATSATIET LESPRERAAL
     TGFSLIRLPD QEKWSGDGAG LKAITGGDAV SVDPKYRDAY STHIPAVILA VNNNPMRFTD
     RSGGVSRRRV IIHFPEQIAP QERDPQLKDK ITRELAVIVR HLMQKFSDPM LARSLLQSQQ
     NSDEALNIKR DADPTFDFIG YLETLPQTSG MYMGNASIIP RNYRKYLYHA YLAYMEANGY
     RNVLSLKMFG LGLPVMLKEY GLNYEKRHTK QGIQTNLTLK EESYGDWLPK CDDPATA
//
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