ID D6IC86_ECOLX Unreviewed; 777 AA.
AC D6IC86;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=DNA primase {ECO:0000313|EMBL:EFF05073.2};
GN ORFNames=ECDG_03496 {ECO:0000313|EMBL:EFF05073.2};
OS Escherichia coli B185.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=550676 {ECO:0000313|EMBL:EFF05073.2, ECO:0000313|Proteomes:UP000004669};
RN [1] {ECO:0000313|EMBL:EFF05073.2, ECO:0000313|Proteomes:UP000004669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B185 {ECO:0000313|EMBL:EFF05073.2,
RC ECO:0000313|Proteomes:UP000004669};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Escherichia coli B185.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG749174; EFF05073.2; -; Genomic_DNA.
DR RefSeq; WP_000783692.1; NZ_GG749174.1.
DR AlphaFoldDB; D6IC86; -.
DR Proteomes; UP000004669; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003896; F:DNA primase activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01029; TOPRIM_primases; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR InterPro; IPR004968; DNA_primase/NTPase_C.
DR InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR InterPro; IPR045455; NrS-1_pol-like_helicase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014818; Phage/plasmid_primase_P4_C.
DR InterPro; IPR013237; Phage_T7_Gp4_N.
DR InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35372; ATP BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR35372:SF2; SF3 HELICASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08706; D5_N; 1.
DR Pfam; PF19263; DUF5906; 1.
DR Pfam; PF03288; Pox_D5; 1.
DR Pfam; PF08273; Prim_Zn_Ribbon; 1.
DR Pfam; PF13362; Toprim_3; 1.
DR SMART; SM00885; D5_N; 1.
DR SMART; SM00778; Prim_Zn_Ribbon; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51206; SF3_HELICASE_1; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Primosome {ECO:0000256|ARBA:ARBA00022515};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 208..296
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT DOMAIN 474..627
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51206"
SQ SEQUENCE 777 AA; 84806 MW; 90508E2E5C1264C9 CRC64;
MKMNVTATVS HALGHWPRIL PALGIQVLKN RHQPCPVCGG SDRFRFDDRE GRGTWYCNQC
GAGDGLKLVE KVFGVSPSDA ATKVAAVTGS LPPADPAVTA AAVAETEAAR KNAAALAQTL
MAKTRPGTGN AYLTRKGFPG RECRMLTGTH RAGGVSWRAG DLVVSLYDDS GELVNLQLIS
ADGRKRTLKG GQVRGTCHTL EGQNQAGKRL WIAEGYATAL TVHHLTGETV MVALSSVNLL
SLASLARQKH PACQIVLAAD RDLSGDGQKK AAAAADACEG VVALPPVFGD WNDAFTQYGG
EATRKAIYDA IRPPAESPFD TMSEAEFSAM STSEKAMRIY EHYGEALAVD ANGQLLSRYE
NGVWKVLPPQ DFARDVAGLF QRLRAPFSSG KVASVVDTLK LIIPQQEAPS RCLIGFRNGV
LDTQNGTFHP HSPSHWMRTL CDVDFTPPVE GETLETHAPA FWRWLDRAAG GRAEKRDVIL
AALFMVLANR YDWQLFLEVT GPGGSGKSIM AEIATLLAGE DNATSATIET LESPRERAAL
TGFSLIRLPD QEKWSGDGAG LKAITGGDAV SVDPKYRDAY STHIPAVILA VNNNPMRFTD
RSGGVSRRRV IIHFPEQIAP QERDPQLKDK ITRELAVIVR HLMQKFSDPM LARSLLQSQQ
NSDEALNIKR DADPTFDFIG YLETLPQTSG MYMGNASIIP RNYRKYLYHA YLAYMEANGY
RNVLSLKMFG LGLPVMLKEY GLNYEKRHTK QGIQTNLTLK EESYGDWLPK CDDPATA
//