ID   D6K4R4_9ACTN            Unreviewed;       591 AA.
AC   D6K4R4;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Tetracenomycin polyketide synthesis hydroxylase TcmG {ECO:0000313|EMBL:EFF91726.2};
GN   ORFNames=SSTG_02045 {ECO:0000313|EMBL:EFF91726.2};
OS   Streptomyces sp. e14.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=645465 {ECO:0000313|EMBL:EFF91726.2, ECO:0000313|Proteomes:UP000004704};
RN   [1] {ECO:0000313|EMBL:EFF91726.2, ECO:0000313|Proteomes:UP000004704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=e14 {ECO:0000313|Proteomes:UP000004704};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Streptomyces sp. strain e14.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; GG753626; EFF91726.2; -; Genomic_DNA.
DR   AlphaFoldDB; D6K4R4; -.
DR   STRING; 645465.SSTG_02045; -.
DR   eggNOG; COG0654; Bacteria.
DR   Proteomes; UP000004704; Unassembled WGS sequence.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   Gene3D; 3.40.30.120; -; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR43004:SF6; FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR43004; TRK SYSTEM POTASSIUM UPTAKE PROTEIN; 1.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   Pfam; PF21274; Rng_hyd_C; 1.
DR   PRINTS; PR00420; RNGMNOXGNASE.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000004704}.
FT   DOMAIN          52..404
FT                   /note="FAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01494"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   591 AA;  64071 MW;  343DAE31185AFD61 CRC64;
     MHHKGDHAGD RPRERTRTGR PAGMETPMRP HRPHPRTPLL EASMRQEADH RVPVLIVGGS
     LVGLSTSLFL GRLGVPHLLV ERHSGTSRHP RGRGNNVRTM ELYRVAGIED DIKAAASLLA
     DNHGILQTPT LVGDAGEWLF KHIDPGGGLA RFSPTGWCLC SQNDLEPVLV EGARRLGGDL
     RYSHELETFE QDGDGVTATL RDRATDERYT VRADYLVAAD GPRSPARNRL GIGQSGPGDL
     FANVSVTFRS KLLADVVGDR RFICCYLTHP DADGALLPVD NKEHWVFHAP WHPERGESLD
     EFTEERLQRH IRRAIGAPDL DVEITGKASW RAAERVADRY TAGRVFLAGD SAHEMSPTGA
     FGSNTGIQDA HNLAWKLAAV LDGWAGPGLL DTYDAERRPV ALATSARASA RSVEHSHPGF
     APAPGIGGGR RGGILNVVLG YRYPEGAVVG ADPAQDVVPD AVRLTGEPGT RAPHLWLRHE
     GERISTLDLY ERSLVLLSDG RSEAGWHTAA RRIAETDGIP LASYRFGADL VHEPQGTDAA
     PAPDWSAAHG TTLDGAVLVR PDGFVAWRSS TPPQDPEGTL RKVLTELLHT A
//