ID   D6K6J4_9ACTN            Unreviewed;       652 AA.
AC   D6K6J4;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Acetoacetate-CoA ligase {ECO:0000313|EMBL:EFF89942.2};
GN   ORFNames=SSTG_00260 {ECO:0000313|EMBL:EFF89942.2};
OS   Streptomyces sp. e14.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=645465 {ECO:0000313|EMBL:EFF89942.2, ECO:0000313|Proteomes:UP000004704};
RN   [1] {ECO:0000313|EMBL:EFF89942.2, ECO:0000313|Proteomes:UP000004704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=e14 {ECO:0000313|Proteomes:UP000004704};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Streptomyces sp. strain e14.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG753626; EFF89942.2; -; Genomic_DNA.
DR   AlphaFoldDB; D6K6J4; -.
DR   STRING; 645465.SSTG_00260; -.
DR   eggNOG; COG0365; Bacteria.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000004704; Unassembled WGS sequence.
DR   GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd05943; AACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR005914; Acac_CoA_synth.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR   PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EFF89942.2};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004704}.
FT   DOMAIN          38..94
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          96..469
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          536..611
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   652 AA;  71874 MW;  BECDEBFE092F5AA2 CRC64;
     MNPQPLWQPD PQRTADAQIT EFQAWAAEHH GAPAEGGYPA LHRWSVEQLD TFWKAVTEWF
     DVRFSTPYAR VLGDRSMPGA EWFPGARLNY AEHALRAADA RPDEPALLHL DETHEPRPVS
     WAELRRQVGS LAAELRALGV RPGDRVSGYL PNVPQAVVAL LATAAVGGVW TSCAPDFGAR
     SVLDRFQQVE PVVLFTVDGY RYGGKEHDRR DVVAELRREL PTLRAVVHIP LLGTPAPEDA
     LEWSALTSAD VAPVFEQVPF DHPLWVLYSS GTTGLPKAIV QPQGGILVEH LKQLGLHCDL
     GPRDRFFWYT STGWMMWNFL VSGLLTGTTI VLYDGSPGHP DTGAQWRVAE RTGATLFGTS
     AAYVMACRKA EVHPARDFDL SSVRCVATTG SPLPPDGFRW LHDEVGDDVW IASVSGGTDV
     CSCFAGAVPT LPVYIGELQA PCLGTDLQSW DPSGAPLTDE VGELVVVNPM PSMPIHFWND
     PDGSRYHDSY FAMYPGVWRH GDWITLTSRG SVIIHGRSDS TLNRQGVRMG SADIYEAVER
     LPEIKESLVI GVEQPDGGYW MPLFVHLAPG AVLDDALLDR VKRTIREQLS PRHVPDEIIA
     VPGIPHTLTG KRIEVPVKRL LQGTPLEKAV NPGSIDDLDL LRFYEDLARK RA
//