ID D6M3H6_STRSH Unreviewed; 820 AA.
AC D6M3H6;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Linear gramicidin synthetase LgrC {ECO:0000313|EMBL:EFG64492.2};
GN ORFNames=SSBG_05278 {ECO:0000313|EMBL:EFG64492.2};
OS Streptomyces sp. (strain SPB074).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=465543 {ECO:0000313|EMBL:EFG64492.2, ECO:0000313|Proteomes:UP000002779};
RN [1] {ECO:0000313|Proteomes:UP000002779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SPB074 {ECO:0000313|Proteomes:UP000002779};
RG The Broad Institute Genome Sequencing Platform;
RA Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Straight P., Clardy J.,
RA Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T., Lander E.,
RA Galagan J., Nusbaum C., Birren B.;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EFG64492.2, ECO:0000313|Proteomes:UP000002779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SPB074 {ECO:0000313|Proteomes:UP000002779};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Streptomyces sp. strain SPB74.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG770539; EFG64492.2; -; Genomic_DNA.
DR AlphaFoldDB; D6M3H6; -.
DR Proteomes; UP000002779; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
FT DOMAIN 261..609
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 667..702
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT REGION 701..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 86117 MW; D2B2C04356E6B919 CRC64;
MRGVAVPLGP LRTDQEARTA VSGNTRNRES LTTEAATAQD HWTGRFAAEV PGTSLPQDFP
HSREAGPRAV RTRALGTDGT GAGDQLTRLA AFAALLHRYG GGAEDLTIAC AGLPLRLGLH
GVRTFAELRA HVAEVREQAE AHRLPTAELL ALLAPEEGRG GTVLCATGFG PAAWDEGGPL
DLALTVTDGE IRAEYATALF TPGTIDRVLG HYATLLADAS ARPGTPLAAL ALLDATERHR
LLVEWNDTTH DVPARTWPRL FAEQVAARPD EIALVHEDEQ LTYAQLDARA ARLAHALVAR
GAGPERVVAL AVPRSADMIV AEVAVLKAGA AYLPVDTDYP AERIAYMLDD ARPVCLVTTA
EVLPDLPRDA VDTLVLDAPE TVAALAALPA EDPEAAAGLT VAHAAYVIYT SGSTGRPKGV
VLSHGGVAKL LATQRERFGI GPHSRVLQFA SPSFDVAFWD LCLGLLSGGR LVVVPADRRV
PGAPLADYAH AHGITFMILP PALLAAMPED VELPPTATLL AGTERVSPEL VGRYARGRMM
FNAYGPTEAT TNSTLGLCDP DTPAGHIVPI GVPDPGTRAY VLDAALRPVP AGVVGELYLG
GAGLARGYLG RPALTAERFV ADPFGTPGER LYRTGDLVRW KADGRLEFHG RADSQTKIRG
FRVEPSEIES VLRAHPAVGQ AAVVVREDRP GDRRLAAYVV PSLTAENKTR PSPSGRASTN
SSTPPPDRTA SRRTSRAGTA CTTASRCRSP TCASGGTRPS PASRSCVPGA SWRSASAAGC
SCPASLPAAP STGARTCPRR PCGPCAPRSR PCPRSRTASR
//
