ID D6NUR3_9HIV1 Unreviewed; 784 AA.
AC D6NUR3;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ADF84092.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADF84092.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADF84092.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S3575TOB8U {ECO:0000313|EMBL:ADF84092.1};
RX PubMed=20231689; DOI=10.4049/jimmunol.0903745;
RA John M., Heckerman D., James I., Park L.P., Carlson J.M., Chopra A.,
RA Gaudieri S., Nolan D., Haas D.W., Riddler S.A., Haubrich R., Mallal S.;
RT "Adaptive interactions between HLA and HIV-1: highly divergent selection
RT imposed by HLA class I molecules with common supertype motifs.";
RL J. Immunol. 184:4368-4377(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; GU728052; ADF84092.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ADF84092.1};
KW Virion {ECO:0000313|EMBL:ADF84092.1}.
FT TRANSMEM 514..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..513
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 532..721
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 723..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 784
FT /evidence="ECO:0000313|EMBL:ADF84092.1"
SQ SEQUENCE 784 AA; 88705 MW; B42614A1B855061F CRC64;
MTVMGIRKNY QHLWKWGIML LGMLMICSAE ENLWVTVYYG VPVWKEATTT LFCASDAKAY
DTEAHNVWAT HACVPTDPNP QEVVMGNVTE XFNMWKNNMV EQMHEDIISL WDQSLKPCVK
LTPLCVTLNC TDFNGTSTNN TRLNTNSNSW ERMEKGEIKN CSFNITSGIR DKVQKAHVLF
YKIDIVPIDN GNVTYRLISC NTSVITQACP KVSFEPIPIX YCAPAGFAIL RCNNKKFNGT
GPCKNVSTXQ CTHGIRPTVS TQLLLNGSLA EEEVVIRSEN FTNNAKTIIV QLNETVKINC
TRPNNNTRKS ISIGPGRAFY ATGDIIGDIR KAHCNVSREE WNKTLEKVAK KLREQFENKT
IVFKPSSGGD PEIVTHSFNC GGEFFYCNTT PLFNSTWNPX XXXXXXSNNT EGPNNITLSC
RIKQIXNRWQ EVGKAMYAPP ISXQIXCSXN ITGLLLTRDG GSXXXXXXXF RPGGGDMKDN
WRSELYKYKV VKIEPLGIAP TKAKRRVVQR EKRAVGLGAM FIGFLGAAGS TMGAASMTLT
VQARQLLSGI VQQQSNLLRA IEAQQHLLQL TVWGIKQLQA RVLAVEKYLK DQQLLGIWGC
SGKLICTTAV PWNTSWSNKS LSSIWDNMTW MEWEREISNY TDLIYNLIEK SQNQQEKNEQ
ELLELDKWAS LWNWFDITNW LWYIKLFIMI VGGLIGLRIV FSVLSIVNRV RQGYSPLSFQ
TRFPVPRGPD RPDGTEEEGG ERDRDRSGPL VDGFLTLIWI DLRSLFLFSY HRLRDLVLIV
ARIV
//
