ID D6NUY4_9HIV1 Unreviewed; 781 AA.
AC D6NUY4;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ADF84163.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADF84163.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADF84163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H0525TOB8U {ECO:0000313|EMBL:ADF84163.1};
RX PubMed=20231689; DOI=10.4049/jimmunol.0903745;
RA John M., Heckerman D., James I., Park L.P., Carlson J.M., Chopra A.,
RA Gaudieri S., Nolan D., Haas D.W., Riddler S.A., Haubrich R., Mallal S.;
RT "Adaptive interactions between HLA and HIV-1: highly divergent selection
RT imposed by HLA class I molecules with common supertype motifs.";
RL J. Immunol. 184:4368-4377(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; GU728128; ADF84163.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:ADF84163.1};
KW Virion {ECO:0000313|EMBL:ADF84163.1}.
FT DOMAIN 34..518
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 537..726
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 726..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 115
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:ADF84163.1"
FT UNSURE 691
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:ADF84163.1"
FT NON_TER 781
FT /evidence="ECO:0000313|EMBL:ADF84163.1"
SQ SEQUENCE 781 AA; 88485 MW; BBFA9E2A157B713E CRC64;
MRVKGIKKNY QHLWRWGIML IGILMICSAT DKXWVTVYYG VPVWKEAXTT LFCASDXKAX
DXEVHNVWXT HACVPTDXNP QEIPLKNVTE NFNXWKNNMX EZMHEDIIXL WDXSXKXXVK
XTPLCVTLNC TDYNGTATNN TXGNTTDTNS GNDTTSGRGE IMKXCSFNIT TNIXDXVXKE
YAIFYKLDVV PIGNDBVSYR LISCNTSVLT QACPKVTFEP IPIHYCAPAG FAILKCNNKD
FNGTGPCTNV STVQCTHGIR PVISTQLLLN GSLXEQEVVI RSKNFXDNTK TIIVQLKEPV
VINCTRPNNX TEKRITLGPG RVXYTTGKII GNXRKAHCNI SKVQWNNTLX QIVXKLRXQY
GKNKTIAFNQ SSGGDPEIVT HXFNCAXEFF YCTTTQLFNS TWYTNSTGNE XXDXGNITXQ
CRIKQIVNLW QEVGKAMYAP PISGXIKCSS NITGLLLTRD GGNRNESREN ETEIFRPGGG
DMRDNWRSEL YKYKVVKIEP LGVAPTKAKR RVVQREKRAV GIGAXLLGFL GAAGSTMGAA
SXTLTVQARQ LLSGIVQQQN NLLRAIEAQQ HLLQLTVWGI KQLQARVLAV ERYLKDQQLL
GIWGCXGRLI CTTAVPWNTS WSNKSLSEIW DNMTWLEWER EIDNYTXIIY TLIEESQNQQ
EKNEQELLEL DKWASLWXWF DIXHWLWYIK XFIMIVGGLV GLRIVFAVLS IVKRVRQGYS
PLSFQTRLPA QGEPDRPEGX EEGGGERDRD RSIRLVDGFL AIFWDDLRSL CLFSYHRLRD
L
//
