ID D6REV1_MOUSE Unreviewed; 1370 AA.
AC D6REV1; F8VQA8;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=ASXL transcriptional regulator 2 {ECO:0000313|Ensembl:ENSMUSP00000117384.3};
GN Name=Asxl2 {ECO:0000313|Ensembl:ENSMUSP00000117384.3,
GN ECO:0000313|MGI:MGI:1922552};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117384.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000117384.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117384.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0007829|PubMed:24129315}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24129315;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000117384.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117384.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Asx family. {ECO:0000256|ARBA:ARBA00006391}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_766009.2; NM_172421.5.
DR SMR; D6REV1; -.
DR jPOST; D6REV1; -.
DR MaxQB; D6REV1; -.
DR ProteomicsDB; 327060; -.
DR Antibodypedia; 27772; 66 antibodies from 17 providers.
DR DNASU; 75302; -.
DR Ensembl; ENSMUST00000153102.9; ENSMUSP00000117384.3; ENSMUSG00000037486.19.
DR GeneID; 75302; -.
DR KEGG; mmu:75302; -.
DR UCSC; uc033gcf.1; mouse.
DR AGR; MGI:1922552; -.
DR CTD; 55252; -.
DR MGI; MGI:1922552; Asxl2.
DR VEuPathDB; HostDB:ENSMUSG00000037486; -.
DR GeneTree; ENSGT00520000055578; -.
DR HOGENOM; CLU_005155_0_0_1; -.
DR OMA; WELKQSE; -.
DR OrthoDB; 3642313at2759; -.
DR PhylomeDB; D6REV1; -.
DR BioGRID-ORCS; 75302; 12 hits in 81 CRISPR screens.
DR ChiTaRS; Asxl2; mouse.
DR Proteomes; UP000000589; Chromosome 12.
DR Bgee; ENSMUSG00000037486; Expressed in lumbar dorsal root ganglion and 245 other cell types or tissues.
DR ExpressionAtlas; D6REV1; baseline and differential.
DR Genevisible; D6REV1; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR026905; ASX-like_PHD.
DR InterPro; IPR024811; ASX/ASX-like.
DR InterPro; IPR028020; ASX_DEUBAD_dom.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR044867; DEUBAD_dom.
DR PANTHER; PTHR13578; ADDITIONAL SEX COMBS LIKE PROTEIN ASXL; 1.
DR PANTHER; PTHR13578:SF11; POLYCOMB GROUP PROTEIN ASXL2-RELATED; 1.
DR Pfam; PF13919; ASXH; 1.
DR Pfam; PF05066; HARE-HTH; 1.
DR Pfam; PF13922; PHD_3; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51913; HTH_HARE; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:D6REV1,
KW ECO:0007829|MaxQB:D6REV1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 11..86
FT /note="HTH HARE-type"
FT /evidence="ECO:0000259|PROSITE:PS51913"
FT DOMAIN 229..338
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 91..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1370 AA; 147065 MW; AFFC42009DF1A8F1 CRC64;
MREKGRRKKG RTWAEAAKTV LEKYPNTPMS HKEILQVIQR EGLKEIRSGT SPLACLNAML
HTNSRGEEGI FYKVPGRMGV YTLKKDVPDG VKELSEGSEE SSDGQSDSQS SENSSSSDGG
SNKEGRKSRW KRKVSSRLSH PPSPPSGCPS PTIPASKVIS PSQKHSKKAL KQALKQQQQK
KKQQQCRPSM SISNQHLSLK TVKAASDSVP AKPGQMKRTK CADIDVETPD SILVNTNLRA
LINKHTFSVL PGDCQQRLLL LLPEVDRQVG PDGLMKLNGS ALNNEFFTSA AQGWKERLSE
GEFTPEMQVR IRQEIEKEKK VELWKEQFFE NYYGQSSGLS LEDSQKLTAS SSDPKAKKTP
AEQPKSILPS EASPVRIVPV VPQSECKEEA VQIPSPSQKE ENQDEARPDS KSPEPVLASA
SNTNELITMK PIKSPKDEGL LEQKPVACAE QESEKENHVT TTSRNNKSEN QEALAISPSK
SKNAGLQKPI IKPVAEASPL NPDMKMPPAT VTDQIQESLK RKSSLTDEEA TSSWEKRPRI
TENRQHQQPF QVSPQPFLNR GDRVQVRKVP PLKIPVSRIS PMLFSTSQVS PRARFPISIT
SPYRTGARTL ADIKAKAQLV KAQKAAAAAA AAAAAAASVG GTIPGPGPGG GQSPREGGER
KIAGGGSAGS DPVSTNGKGP TLELAGTGSR GGTRELLPCG PQPETNMPGQ AQPPGISGAQ
LQQTSSVPTG LASSGACTSV PLPAHIEISN SEKPNLHKAT ATAASPCHLQ DPRSCRLEKA
LSPTGPPLIS GASTVYFVAD GTVEPKAGSN KNAPKPSALA KTTAPAPLDM TSSPVTTASL
EKLPVPQISG TATSTGSAPS SSTLPAASSL KTPGTSANMN GPISRTSSSI PANNPLVTQL
LQGKDVPLEQ ILPKPLTKIE MKTVPLTTKE EKGIGIFPGI SVMESSSREE VNGRQAHLAI
PQLGKPLQSK QLSQVPRPVF TAKDRKDPCI DTHQYREGLS KTTQDQLFQT LIQRAQRQSV
LSFVPPSQFN FAHSGFHLED ISTSQKFMLG FAGRRTSKPA MAGHYLLNIS TYGRGTENIK
RTHSVNPDDR FCLSSPTEAL RMGHADYKNT TGEISSKEDE SDEDRVGDEQ EPISVKEEPW
ASQSSGRHPH HGEASSTNDC LASKNGKTEA PVSEQTTLGQ ENYIFSRGQA SDEKSLPRDF
IPAAHKQMTH AVRGKTVCSS PELFNSTALS LPADSPTHQP LLLPPLQTPK LYGSPTQIGP
SYRGMINVST SSDMDHNSAI PGSQVSSNVG DVMSFSVTVT TIPASQAMNP SSHGQTIPVQ
TFPDDNSIED TPSKCYCRLK AMIMCKGCGA FCHDDCIGPS KLCVSCLVVR
//
