ID D6RFM7_HUMAN Unreviewed; 83 AA.
AC D6RFM7;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Anaphase promoting complex subunit 4 {ECO:0000313|Ensembl:ENSP00000426512.1};
GN Name=ANAPC4 {ECO:0000313|Ensembl:ENSP00000426512.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426512.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000426512.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000426512.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC108218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC110812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; D6RFM7; -.
DR SMR; D6RFM7; -.
DR MassIVE; D6RFM7; -.
DR MaxQB; D6RFM7; -.
DR PeptideAtlas; D6RFM7; -.
DR ProteomicsDB; 14580; -.
DR Ensembl; ENST00000505080.1; ENSP00000426512.1; ENSG00000053900.11.
DR UCSC; uc062vre.1; human.
DR HGNC; HGNC:19990; ANAPC4.
DR VEuPathDB; HostDB:ENSG00000053900; -.
DR GeneTree; ENSGT00390000004612; -.
DR HOGENOM; CLU_2557705_0_0_1; -.
DR ChiTaRS; ANAPC4; human.
DR Proteomes; UP000005640; Chromosome 4.
DR Bgee; ENSG00000053900; Expressed in oviduct epithelium and 187 other cell types or tissues.
DR ExpressionAtlas; D6RFM7; baseline and differential.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR InterPro; IPR024789; APC4.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR PANTHER; PTHR13260; ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4; 1.
DR PANTHER; PTHR13260:SF0; ANAPHASE-PROMOTING COMPLEX SUBUNIT 4; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
PE 1: Evidence at protein level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Proteomics identification {ECO:0007829|EPD:D6RFM7,
KW ECO:0007829|MaxQB:D6RFM7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 27..64
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 83 AA; 9709 MW; 085C126764DC3626 CRC64;
MLRFPTCFPS FRVVGEKQLP QEIIFLVWSP KRDLIALANT AGEVLLHRLA SFHRVWSFPP
NENTGKEFWP LLLLIPRKLF CVM
//
