ID D6RGF6_HUMAN Unreviewed; 153 AA.
AC D6RGF6;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=LRP2-binding protein {ECO:0000256|ARBA:ARBA00039954};
DE Flags: Fragment;
GN Name=LRP2BP {ECO:0000313|Ensembl:ENSP00000421244.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421244.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000421244.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000421244.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May act as an adapter that regulates LRP2 function.
CC {ECO:0000256|ARBA:ARBA00037614}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AC073344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC106897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; D6RGF6; -.
DR SMR; D6RGF6; -.
DR MassIVE; D6RGF6; -.
DR PeptideAtlas; D6RGF6; -.
DR ProteomicsDB; 14684; -.
DR Antibodypedia; 28937; 78 antibodies from 18 providers.
DR Ensembl; ENST00000511404.1; ENSP00000421244.1; ENSG00000109771.16.
DR UCSC; uc063bjv.1; human.
DR HGNC; HGNC:25434; LRP2BP.
DR VEuPathDB; HostDB:ENSG00000109771; -.
DR GeneTree; ENSGT00390000013490; -.
DR HOGENOM; CLU_112507_0_0_1; -.
DR OMA; TDHYTHA; -.
DR Proteomes; UP000005640; Chromosome 4.
DR Bgee; ENSG00000109771; Expressed in sperm and 107 other cell types or tissues.
DR ExpressionAtlas; D6RGF6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44554; LRP2-BINDING PROTEIN; 1.
DR PANTHER; PTHR44554:SF1; LRP2-BINDING PROTEIN; 1.
DR Pfam; PF08238; Sel1; 2.
DR SMART; SM00671; SEL1; 1.
DR SUPFAM; SSF81901; HCP-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Proteomics identification {ECO:0007829|PeptideAtlas:D6RGF6,
KW ECO:0007829|ProteomicsDB:D6RGF6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 59..92
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT NON_TER 153
FT /evidence="ECO:0000313|Ensembl:ENSP00000421244.1"
SQ SEQUENCE 153 AA; 17845 MW; F03F11F500E85BF2 CRC64;
MKLTSEKLPK NPFYASVSQY AAKNQKFFQW KKEKTDYTHA NLVDKALQLL KERILKGDTL
AYFLRGQLYF EEGWYEEALE QFEEIKEKDH QATYQLGVMY YDGLGTTLDA EKGVDYMKKI
LDSPCPKARH LKFAAAYNLG RAYYEGKGVK RSN
//
