ID D6W834_TRICA Unreviewed; 1174 AA.
AC D6W834;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-3-like Protein {ECO:0000313|EMBL:EFA11006.2};
GN Name=AUGUSTUS-3.0.2_04591 {ECO:0000313|EMBL:EFA11006.2};
GN ORFNames=TcasGA2_TC004591 {ECO:0000313|EMBL:EFA11006.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA11006.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA11006.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA11006.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA11006.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA11006.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971307; EFA11006.2; -; Genomic_DNA.
DR RefSeq; XP_015836573.1; XM_015981087.1.
DR AlphaFoldDB; D6W834; -.
DR STRING; 7070.D6W834; -.
DR EnsemblMetazoa; TC004591_001; TC004591_001; TC004591.
DR GeneID; 660639; -.
DR KEGG; tca:660639; -.
DR eggNOG; KOG2353; Eukaryota.
DR HOGENOM; CLU_004660_1_1_1; -.
DR InParanoid; D6W834; -.
DR OMA; ACDMRST; -.
DR OrthoDB; 2971287at2759; -.
DR Proteomes; UP000007266; Linkage group 1.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166:SF31; CA[2+] CHANNEL MUSCLE-SPECIFIC ALPHA2_DELTA SUBUNIT, ISOFORM A; 1.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF13519; VWA_2; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1174
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007310529"
FT DOMAIN 251..449
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1174 AA; 136242 MW; 52AA59DEC1DBEB1D CRC64;
MMFLQKHCTE FFLLSLFTAT VQCTKLQEEQ VSRWAKKIGD ELWKLGEVTT KFKEIQGNYV
YLNAQVETKD LENLISEVGK DIERMMDRKS DAIKCIIEEA ENLSQYWVYN NSEYQYYSSK
YSNVVNETKI NLAQLSEALK RNENMYLEMV LNDDTHFYNL AVDTSRSSVH VPTNIFDRHE
EAAYAIQWSE KLDEIFVRNY NSDPALSWQY FGSTSGIMRH YPAKKWPNIE KDEFDCRVRT
WYIEAATCTK DVIILVDNSG SMDGMGRHIA SLTVNTILDT FSNNDYINIL YYSNQTTNYT
IPCFRNLLVQ ATPENIVLFK EAIRHLGPSG KTDFPQALQM AFDILENYRE IRGCNNEEID
EEGKSKACNQ AIMLITDGIS RNFSDIVMRN NQLDGGKTIP VRIFTYLIGK EVTNVEEIRW
MACANRGFYT QVQTLEQVTS AVLQYINVIA RPLVLQGEDH PISWTHAYID MTYDDNKDDQ
INEPYRLLTS AAVPAFDKKV NQNNETRVAN LLGVAGTDVP IADIEKLTLP YKLGVNAYAF
IVSNNGYILM HQDFRPMFQK HLRKNYNSID LVEVEEFDTE LPPRHFHPDL KTLRNSIVNG
SQGSIHGIPV KYHYDNMRRV TRDKYDYYYV PLNQTPFSLA FAVPDGYGHF SLHVEDEIKN
DRHKPGVKIT DYFNGSNWKI HPKWVYCKYH YLEGHEYETP EKEILHFLGK VYENDFKWRK
QYEAGAGEEL TKVECGRRSH GNDDYYCDKD LVQRLVFDAK NTFGAFQGTS WKHDTDRLFR
RFNATLRFVA TMSGLTRWEY ISEEVENNTE REFGDLHAEA IDETWYKSAV IHHRYDPESF
VYSVPFDSGL QEDLLVTASY AVFPTDAGKM APGCVVGFQF AHKNFMEIVQ EITANVSIEC
NKDCGKCGVD LKCYLIDNDG YIIVSENVQD TGKFFGEIEG DIMGSMLEKK FFEKVIIYDY
QAVCNTKDDE TSDATVLLTP INYVRFLANW LIMKISWLAF EINIYNFWAP FHVFAQDEKE
DGVLIETKED DDENEEEEEE EDTYYDCEQE RDLFFMLHNN KSYDFPGDIS GQGFRHYYIK
KVPYSNLIFV AINATMPRTN QQVYSTSPRK IVYSDNADYP CQKLDLNNLP RRRLAGCYNE
HPLESEIKVC GKTATIKNQF LVTLVMCLFL LQNT
//
