ID D6WIU3_TRICA Unreviewed; 1551 AA.
AC D6WIU3;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFA01095.2};
GN Name=GLEAN_04018 {ECO:0000313|EMBL:EFA01095.2};
GN ORFNames=TcasGA2_TC004018 {ECO:0000313|EMBL:EFA01095.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA01095.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA01095.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA01095.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA01095.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA01095.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971336; EFA01095.2; -; Genomic_DNA.
DR EnsemblMetazoa; TC004018_001; TC004018_001; TC004018.
DR HOGENOM; CLU_001356_5_0_1; -.
DR Proteomes; UP000007266; Linkage group 3.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF3; PURATROPHIN-1-LIKE, ISOFORM A; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266}.
FT DOMAIN 1103..1283
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1295..1406
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1477..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 682..709
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 803..837
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 13..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1551 AA; 175730 MW; 7EF87AA1B10C32FF CRC64;
MIRRNRKVTP TGRHALTYDE ESWRSTSEES SSKPPEELSR SSDTRQSATK RVKNYLKKCK
NALKSGSHEE VASTSSWYLD ELINVSEVNE LEDIYEDVQV DVDSGVYQVA SVVDVVDRNE
DAGAQSSPPL TEEQGKVDGD VGEGQKPAVK SDVATLVDKY FGNLYENFER SKKCLVRQAR
DLLVCEYHGC LHRFENEFCI QAAKLLERVK TDNFSFGVCE RVHFWWFLSV LVLCYFSDRI
TLLKCKAPLS GSAPLGWPLC LGPAGVAVHL GPLDASVLRN SDCYLCIRGT PGVELALVWR
QNSRIHSHTV AEFTDRNCED IMCSNLRSVA DLELMSYDDY DGAELPELLQ NLLVSVEHAI
ERVPLDDLTF PCPQCLQYLP VERREDEVMA CACQCACRES PVVVKRDSAM QTSPMFEFAG
SIPHIDSDEE EDKESIKSGS SNRKKLLMSG INLPGTADND GRPIVLCYAE CVLRAGLNKY
EIAKLLLYYS SIPTLESARN GFTILLLAEN ENSSKVLELL DKSAALVVNT MKIDRLLVWK
PGSEQDRNQV TSSRIPAIVI CDEATLCKYL TKEETPASCG GSCSHDQLEW VEFFKQVEPF
LTSCKAAGRS LLSVLTQLRN EDLPHQITRR FLNHQCRQIS KALDLDQVMK LRKEGPKTLA
NLKERAQWLS GSKDVKRNVS FSEESFNSLE RVSKRLEQLR QERVERLKEL AKFTSLREEA
DELVSWFRKA GEDNISSLTT KLKSAADILA VKQVSDDFEK LDFIAWRQFE KSTDLIEECK
NIKDPKELNL KETTGNRHFR DKYQTLKESA ASLLAQMKAF RERLEDTKER LEECNRCFML
LDSENEQKDV EEFVKMAERS SNEKLLQKCK AFKRKDTSLP SKPPDRPPSD PPTATSTPIK
TPNTQIRRRS VSSLAFIYHC NHHAAGELCN CCESDTENSV SYKLKKKYIQ TLQTCVCKDT
LERKNSATLD EIKEESVENL LDHRCDSGLS TADNSVGEES VCNNNSKKKV QRTCSCQFSG
CSAGSSSVGS NQDNTENQQD SIIEEDGFNK SSSEDIEEEN YGDEERRKVP PIPANNHLYC
HASSLDLPSD ALYSNMDPKT QKTLTFIIKE MIETERDYVK SLDYIIVNYI PELMREDIPQ
ALRGQRNIIF GNVEKIYEFH SQHFLHELEG CESNPLQVGQ IFLKHDKKFY LYALYNKNKP
KSDSLMSEYG SLFFKSKQLE LKDRMDLASY LLKPVQRMGK YALLLQQMMK ACVGPSMERL
QELEDLKQAE EMVRFKLRHG NDLLAMDSIR ECDVNLKEQG SLLRQNEFLV WEGRNGKKSL
RQVFLFEELI LFSKARRFPD RKNLDLYIYK NSIKMTDIGL TAKIGDSSTK FEIWFRKRKP
NDTFTLQAMS EDVKKAWTEE LSQLLWKQAI KNRAVRMAEM SSMGIGNKPC LDIRPSADQI
SDRSISVDQL SRTAPRFRNS IVGPVIESCR NAKRPHSVIS MSSSVSSGST SSANSGGQNN
SMNLGFESAC DSPKPYHRSA TLNSQCSTES GIIADMSMGS DECSEQPHAG L
//
