ID D6WJR6_TRICA Unreviewed; 1481 AA.
AC D6WJR6;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Alsin-like Protein {ECO:0000313|EMBL:EFA04485.1};
GN Name=AUGUSTUS-3.0.2_14790 {ECO:0000313|EMBL:EFA04485.1};
GN ORFNames=TcasGA2_TC014790 {ECO:0000313|EMBL:EFA04485.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA04485.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA04485.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA04485.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA04485.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA04485.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971343; EFA04485.1; -; Genomic_DNA.
DR RefSeq; XP_001811806.2; XM_001811754.3.
DR STRING; 7070.D6WJR6; -.
DR EnsemblMetazoa; TC014790_001; TC014790_001; TC014790.
DR GeneID; 100142202; -.
DR KEGG; tca:100142202; -.
DR eggNOG; KOG0231; Eukaryota.
DR eggNOG; KOG1426; Eukaryota.
DR HOGENOM; CLU_003333_0_0_1; -.
DR InParanoid; D6WJR6; -.
DR OMA; CIAVYMS; -.
DR OrthoDB; 3740287at2759; -.
DR PhylomeDB; D6WJR6; -.
DR Proteomes; UP000007266; Linkage group 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR CDD; cd13269; PH_alsin; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 4.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR PANTHER; PTHR46089:SF2; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 7.
DR Pfam; PF00415; RCC1; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00698; MORN; 8.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50012; RCC1_3; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266}.
FT REPEAT 485..536
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1346..1481
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 236..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1481 AA; 168209 MW; B46A3744CD4508C5 CRC64;
MANNIRLWNL TQTVQLQTDI KESIKKISNI DNHLYIQTTS NCLYHGIVQT SENSSSLTLD
YCEDWKVIDL DCCKDSLYVV DIDGNVYKCT KNLEKCSEIC LLEDYQCSRG HTGTKCKMKV
SKIAVGEYGQ LFVTDWGHLW AMGHMPQIGI NSDTPRKVNF FNGRTVHSVN VGNDFAIAIV
SKQMKSDDTD SDEEDVFVSN CPQCLSASQL TSPASQTSFS DLCPLGNKIQ GSYDIETTST
SSKNDSSVSS DRRLVHSDDE EEKHDKQKVE KNIIFRNTEA AKEFLTRQIS RMSSAGEEYL
VECTEKPTRI IKENMTNVAS FVYEGVKTVG DKVVTLSRHV SGSSDCNSTM DPNPDLTVPR
SASKDDGVCS LSQCTSEKDL SEGEIKDRVA NIVKSGSELI NCEVWTWGNI IHGQLDCRHL
EPNDCLNNPI RQFLHKFVEA GADKPTGIGD IIKRERPMII TKLSNIGVRK VSVQNYHAAV
LTLDGRAYIW GRNDHNQVTM DTNMDQSSPK LYNMSKDERV KDVVCGAYYT AVLNHNLNLS
YFGKGASKCV DLYCIEGHHE VKEPIVLFRN LLSSMQYTVL NVGSSGDNFF ANFLLEEQKF
LEEMLIVQST VIKPLQKKNI NTANAGLYED LCKSYMDLCY FWAANVQSLL EHCNGLISLC
DIVMFRYLDE FIFVYKNYIS TIFNVISIDG FLNISKLIEI SPNLYKQRPD SFTKKEKNNE
ENIISTYLLA PLDKLETYTT TFDNYSNQLS FVPKWSDFVD EQLHKKQQAE QTRAFWLNSG
KVVDQLKSPD RRLIRDSHKY PIHLQNASRF SSHWFVLFSD LFVHMNGSTA HLHNLTTIWI
EPQQDETSQQ YQICLKMPEE TLVLCTSEPE AKIEWFHALQ NAIKAAMNKS EALQPPVVRN
GSYVFRSNGF FKDGTYTGRW SNGKMQGNGK VQWSDGKAYN GQFCNNQLCG YGVMEIPSVG
IYEGQWKDNQ QNGFGVFTYN NTDVYKGHFK DGQPHGHGFL RKGNFMANAA SFYIGDWVNG
MKNGYGVMDD IANGEKYIGN WMDNKKHGNG LIITSDGIYY EGIFNQDVLT GQGVMILEDG
TRYEGEFRGT GILYGKGTLT LPSGHTIEGN LSGPWDEGIK ISNGTLFRTL EKTPAKTFCS
PVHQKWKALF KQCHQILGVP EKNGAKSLDT QKIWQNVAVY LSNSNSMKRT KNDKKFHNSL
NNLDIIPPFG REKLDLETYT EVKSYLSKAF ESNFHPLGSL LTDLSEAYTT TYGGRAHPLL
LGHAIAELHY ICKRLYEIVR FLFPALPPYD KESLVENEDS EEIVNYQSLL YPLILPKVHH
PLFTLFTLKN EQQERQYKRT LMEWNKQSDT ALMTFLSVDQ KFFHSEDQQI AHIFEDAIET
LQQLKTTFSP TEKLLVIRQT VEKMTPVAQE LLGVNYVWNM DDLFPIFLFV VVRARIPDLG
SELDFVDNFM DPSLESGELG IMYTTLKASY QQILQEKVSS Y
//