ID D6WJX5_TRICA Unreviewed; 2118 AA.
AC D6WJX5;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Myosin-VIIa-like Protein {ECO:0000313|EMBL:EFA03648.1};
GN Name=AUGUSTUS-3.0.2_13742 {ECO:0000313|EMBL:EFA03648.1};
GN ORFNames=TcasGA2_TC013742 {ECO:0000313|EMBL:EFA03648.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA03648.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA03648.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA03648.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA03648.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA03648.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KQ971342; EFA03648.1; -; Genomic_DNA.
DR RefSeq; XP_008193134.1; XM_008194912.2.
DR STRING; 7070.D6WJX5; -.
DR EnsemblMetazoa; TC013742_001; TC013742_001; TC013742.
DR GeneID; 662874; -.
DR KEGG; tca:662874; -.
DR eggNOG; KOG4229; Eukaryota.
DR HOGENOM; CLU_000192_14_1_1; -.
DR InParanoid; D6WJX5; -.
DR OMA; MYEKVWA; -.
DR OrthoDB; 1094820at2759; -.
DR PhylomeDB; D6WJX5; -.
DR Proteomes; UP000007266; Linkage group 5.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692:SF33; MYOSIN; 1.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 66..736
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 962..1194
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1199..1509
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1507..1574
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1649..1797
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1803..2107
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 614..636
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 864..891
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 159..166
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2118 AA; 243623 MW; 8FA589E76647FEF4 CRC64;
MSKTSGLVVG DHIWIQPVTN GEFDILIGGK ITGIEERRIR AKDDDGNEIS ISHQQVVKNM
HVSSVEGVED MINLGDLQDY AILRNLHKRY RSKNIYTYIG SMLVAINPYE VLPIYTNALI
KEYRNKKLNE LPPHIFAIGD NSYVDMKTSR KDQCVVISGE SGAGKTESTK LILQYLASTS
GQHSWIEQQI LEANPIMEAF GNAKTVRNDN SSRFGKYIDI HFNKSGNIEG ARIEQYLLEK
SRIVSQNDGE RNYHIFYSML AGLSKEEKKR FDLTEPDHYV YLKGGRTLTC QGRNEANEFT
DIRGAMKVLN FTDKEANDIF QLLAAILHLG NLKFKAGTAS NTESSEIQDA TAADKIARLL
GSNKFDLGEA LTKKTIFAHG DKVISTLSQE QASESRHAFV KGIYGKLFIM IIEKINSAIY
QPKGASKTSI GVLDIFGFEN FKVNSFEQLC INYANENLQQ FFVQHIFKLE QDYYTKEGIN
WKNIAFVDNQ DVLDMIGMKP MNLMSLIDEE SKFPKGTDFT MLAKLHNTHS AKKNYLKPKS
DVTPAFGVQH FAGPVYYDVP GFLEKNRDSF SQDLKQLIQE SNNELLKQIF AEDFQQETNT
KRTITLSSQF RSSLDILMKT LNMCHPYFVR CIKPNEEKKP QVFDRTLCCR QLRYSGMMET
AKIRQAGYPI RYTYKDFVDR FRHLGKAIPP STKGDCKQST KKICETVFQN NEDFQMGHTK
LFLKAHDHEF LEQERSRILS KYILVLQKAI RGWIFKRRFR KLREATIVFQ KYWRARGYRT
KFLTIRNGYQ RLQASIRSRQ LTHSFGKVRK NIVHLQAVAR GHVVRNKSQF GRIYAIVKQR
KVDEQNMKNA GNKNYRIDAE TKMQKSLAEL NREYTLKLKQ QEEEENKAKK LVDDVFEFLK
DPNLPATPTD IRKENDAFIE LLKDAKSGEK DKTYDEEQED LSAYNFAKFA ATYFIKNTNH
HYSKRPLKES LLDLPTPDDI IAAQALWITI LRFMGDLPEP KFENAIKTNE SVMTQVSQTL
SRSFTNRKEY QDILKDERKM ASLTKSERKK LVSMTLRRKN KLLEDVRQGL VEDNFAAESY
NEWLNNRRAT NLEKLHFIIG HGILRPELRD EIFCQICKQL TNNPTKASHA RGWILLSLCI
GCFPPSDRFL NYLRAFIRSG PPGYAPYCEG RLNRTFKNGA RTQPPSWLEL MATRNKNPIS
LKITFMDNSE QEVEVDSATT SEEICKEIAT KRNLKDVFGF SLFITLFDKV MSLGSDSDHV
MDAISQCEQY AKEKGQSERN APWKLFFRKE IFTPWHNAAD DSVATSLIYH QIIRGLKFGE
YRCSVEGDVV SLVATQYYVD NGAQLNPEIL HTRIGEYMPT YLVKKGQKNL DEWEKRIKDA
FSKLLCVKNK LPAIKAQEFI VKYAKNTWPI LFSKFFEAMQ TGGPELPTKT MIIAVNWTGI
YMIDDQEQIL LELSFCDVSS VSFERIGRSH LHKFVLTTVR NEEYVFVSPD AENICTLIQY
LLDGLKKRST YVVAIQDYKH QTNAPSFLAL KKGDLIALKN GLNGEALMSA TWGYGECNGS
VGDFPTEHVY ILPAITQPPA DILTAFKKEG VFGPKKPSAP VLNTMQRLKL YTLAHYANEH
FRAGKKLVNS KPSVLTAARR ASREELWKYT NEPIYQPHLQ KLLTDEDLSK EACSAFTAIL
KYMGDLPAPK AKYSNEYTDQ IFSGALKNDM LKDEVYCQIM RQLTFNRLSL SEERGWELMY
LATGLFIPSA SLMTELHKFL TSRTHPFVEP CLKRLQRSQK VGPRKYPPYS VEVEAIQHRS
MEIYHKIYFP DDTDEAFEVD SVTRACDLCK TISSRLELEY TDGFSLFVMI SDKVFSIPED
YFFYDFLHEL ISWMRQTKPS WNSAAPIQAQ YQVFFMKKLW INAVPGKDPN ADQIFHFHQE
LPKYLRGFHK CTKQDAIKLA ALVLHSRLDN DYNQAQAAVQ YLKELIPADL VKAASSSEWK
KSILTEFKKL GDISIEKAKL RFLETIYEWP TFGCTFFEVK QTTDPTLPGI ILIGINKLGV
NILHPQTKDI LAVHEFSELS NWSSGNTFFH LTIGNIMRKT KLLCETSQGY KMDDLITSYT
DYIKNTAKKE QEKEKFFL
//
