ID D6X0T5_TRICA Unreviewed; 384 AA.
AC D6X0T5;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog A-like Protein {ECO:0000313|EMBL:EFA09556.1};
GN Name=AUGUSTUS-3.0.2_11666 {ECO:0000313|EMBL:EFA09556.1};
GN ORFNames=TcasGA2_TC011666 {ECO:0000313|EMBL:EFA09556.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA09556.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA09556.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA09556.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA09556.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA09556.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971372; EFA09556.1; -; Genomic_DNA.
DR RefSeq; XP_008198428.1; XM_008200206.2.
DR RefSeq; XP_008198429.1; XM_008200207.2.
DR RefSeq; XP_966668.1; XM_961575.3.
DR AlphaFoldDB; D6X0T5; -.
DR STRING; 7070.D6X0T5; -.
DR EnsemblMetazoa; TC011666_001; TC011666_001; TC011666.
DR GeneID; 655083; -.
DR KEGG; tca:655083; -.
DR eggNOG; KOG3732; Eukaryota.
DR HOGENOM; CLU_048292_0_1_1; -.
DR InParanoid; D6X0T5; -.
DR OMA; QDKDAMG; -.
DR OrthoDB; 3130057at2759; -.
DR PhylomeDB; D6X0T5; -.
DR Proteomes; UP000007266; Linkage group 9.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016442; C:RISC complex; IBA:GO_Central.
DR GO; GO:0070578; C:RISC-loading complex; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0035197; F:siRNA binding; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0070920; P:regulation of regulatory ncRNA processing; IBA:GO_Central.
DR GO; GO:0030422; P:siRNA processing; IBA:GO_Central.
DR CDD; cd19862; DSRM_PRKRA-like_rpt1; 1.
DR CDD; cd19863; DSRM_PRKRA-like_rpt2; 1.
DR CDD; cd19864; DSRM_PRKRA-like_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR InterPro; IPR014720; dsRBD_dom.
DR PANTHER; PTHR46205; LOQUACIOUS, ISOFORM B; 1.
DR PANTHER; PTHR46205:SF3; LOQUACIOUS, ISOFORM B; 1.
DR Pfam; PF00035; dsrm; 2.
DR SMART; SM00358; DSRM; 3.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR PROSITE; PS50137; DS_RBD; 3.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EFA09556.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW Transferase {ECO:0000313|EMBL:EFA09556.1}.
FT DOMAIN 65..133
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 167..235
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 312..380
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
SQ SEQUENCE 384 AA; 42967 MW; 1F65DE0EB201AD2C CRC64;
MFVPPPVEQQ FRMDPNMTLL HSSSQIHNVH PRRKNNRNTL HGMQAERLSL SEEAKLEMAS
LPTKTPVSVL QELLSRRGAT PKYELVQIEG AIHEPIFRYR VFINNDLVAT GTGRSKKDAK
HAAAKNLLDV LVGKQSPEQA NASNGTPGAN DITAQVVSPF DDKVMGNPIG WLQEMCMSRR
WPPPSYEMEH EEGLPHERQF TIACQVLKFK EVGTGKSKKL AKRMAAHKMW QALQDMPLEG
NNLPQGYDDD EELAAKMCNL QGRYSGLKDS KIPTLNIQHT QKVSQFHKAL KQSNGPKLKE
LQNIVLNSKD FNFIQFLHEI ASEQQFEVTY VDIEEKALSG KSQCLVQLST LPVAVCYGAG
ATPKEAQSAA ALNALEYLRI MSKK
//
