ID D7AW31_NOCDD Unreviewed; 406 AA.
AC D7AW31;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Formaldehyde dehydrogenase, glutathione-independent {ECO:0000313|EMBL:ADH69691.1};
DE EC=1.2.1.46 {ECO:0000313|EMBL:ADH69691.1};
GN OrderedLocusNames=Ndas_4302 {ECO:0000313|EMBL:ADH69691.1};
OS Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115 / JCM
OS 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509)
OS (Actinomadura dassonvillei).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=446468 {ECO:0000313|EMBL:ADH69691.1, ECO:0000313|Proteomes:UP000002219};
RN [1] {ECO:0000313|EMBL:ADH69691.1, ECO:0000313|Proteomes:UP000002219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 /
RC NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509
RC {ECO:0000313|Proteomes:UP000002219};
RX PubMed=21304737; DOI=10.4056/sigs.1363462;
RA Sun H., Lapidus A., Nolan M., Lucas S., Del Rio T.G., Tice H., Cheng J.F.,
RA Tapia R., Han C., Goodwin L., Pitluck S., Pagani I., Ivanova N.,
RA Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Djao O.D., Rohde M., Sikorski J.,
RA Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU
RT 509).";
RL Stand. Genomic Sci. 3:325-336(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP002040; ADH69691.1; -; Genomic_DNA.
DR RefSeq; WP_013155298.1; NC_014210.1.
DR AlphaFoldDB; D7AW31; -.
DR STRING; 446468.Ndas_4302; -.
DR KEGG; nda:Ndas_4302; -.
DR eggNOG; COG1063; Bacteria.
DR HOGENOM; CLU_026673_11_3_11; -.
DR OrthoDB; 241504at2; -.
DR Proteomes; UP000002219; Chromosome 1.
DR GO; GO:0018467; F:formaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08282; PFDH_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014184; HCHO_DH_non_GSH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR02819; fdhA_non_GSH; 1.
DR PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ADH69691.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002219};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 44..153
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 206..272
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 406 AA; 42571 MW; C017F861CD744B0A CRC64;
MTGNRGVVYR GAGRVEVEDV DYPEFVIKDG PGVNPANVGR KVPHGAILKV VATNICGSDQ
HMVRGRTTAP EGLVLGHEIT GEVVETGPGV EFVKVGDLVS VPFNISCGRC RNCKARRTEI
CLNVNPDRPG SAYGYVDMGG WVGGQARYAL VPYADWNLLV FPDRDQALEK ILDLTMLSDI
FPTGYHGCVT AGVGVGSSVY VAGAGPVGLA AAASARLLGA AVVIVADMKE ERLAQARSFG
CETVNVAEGD LAGQIERILG VPEVDCAVDA VGFEAHGTGE GASKEAPASV LNTAMDVTRA
GGSIGIPGLY VTGDPGASDE AAKEGSLSVR IGLGWSKSHA FFTGQCPVMK YHRELMEAIL
HDRVRIAEAV NAVAIPLEEA PEGYRAFDEG AASKYVLDPN NYLGTR
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