ID D7BLB3_ARCHD Unreviewed; 881 AA.
AC D7BLB3;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=CRISPR-associated helicase Cas3 {ECO:0000313|EMBL:ADH93443.1};
GN OrderedLocusNames=Arch_1761 {ECO:0000313|EMBL:ADH93443.1};
OS Arcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / CCUG 17215 /
OS LMG 16163 / NBRC 15585 / NCTC 8452 / 11018).
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Arcanobacterium.
OX NCBI_TaxID=644284 {ECO:0000313|EMBL:ADH93443.1, ECO:0000313|Proteomes:UP000000376};
RN [1] {ECO:0000313|EMBL:ADH93443.1, ECO:0000313|Proteomes:UP000000376}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 9345 / DSM 20595 / CCUG 17215 / LMG 16163 / NBRC 15585 /
RC NCTC 8452 / 11018 {ECO:0000313|Proteomes:UP000000376};
RX PubMed=21304742; DOI=10.4056/sigs.1123072;
RA Yasawong M., Teshima H., Lapidus A., Nolan M., Lucas S.,
RA Glavina Del Rio T., Tice H., Cheng J., Bruce D., Detter C., Tapia R.,
RA Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA Mikhailova N., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA Chang Y., Jeffries C., Rohde M., Sikorski J., Pukall R., Goker M.,
RA Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P., Kyrpides N.,
RA Klenk H.;
RT "Complete genome sequence of Arcanobacterium haemolyticum type strain
RT (11018).";
RL Stand. Genomic Sci. 3:126-135(2010).
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CP002045; ADH93443.1; -; Genomic_DNA.
DR RefSeq; WP_013170929.1; NC_014218.1.
DR AlphaFoldDB; D7BLB3; -.
DR STRING; 644284.Arch_1761; -.
DR KEGG; ahe:Arch_1761; -.
DR eggNOG; COG1203; Bacteria.
DR HOGENOM; CLU_013924_1_0_11; -.
DR OrthoDB; 9810236at2; -.
DR Proteomes; UP000000376; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF16; CRISPR-ASSOCIATED NUCLEASE_HELICASE CAS3-RELATED; 1.
DR Pfam; PF18019; Cas3_HD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000376}.
FT DOMAIN 13..219
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
SQ SEQUENCE 881 AA; 98364 MW; A74FAE2C12F34E81 CRC64;
MNTHPELWAK QDGFEKTYPL IAHLLDTVTV AGALYDHWLR PGLRELIEEN LGKQARSIVI
AVMGLHDVGK ANPLFQQRPQ ENGLEWQKIR EIIDSSGNYK PIPPRHILLD RTKIDVRRHE
CSSAYTLQPS PPTEARAASK LWLHLVLGGH HGRFLPVLKR AESTKIQNGY KDYGWEQAQK
DLTDLVLKEC NITTKDIPEK VDPTIVLLLS GLVILADRIA SGALFVDSGF DLLSHEPELL
NDPSSWVTRR KAEAEKRVHN TVGIYSPWPN PQAAREAILG KYSPRPIQQR ALDAGDGLWS
LMATTGSGKT EAALLRHSTR PERLIFLLPT QATSNAIMRR VQHAYQGTCN VAALAHGLAS
VEDFYTKPIS VYDDEAINGQ TLNTTDKPDG LYPSSFVRAG AARLFAPVCV GTIDQALAAS
LPGKWIHFRL LALANAHIVI DEVHTLDPYQ SKLLEGILPW LAKTRTRVTF LTATMPSSQR
EQLLAAYSQG DEPLSPPIFP SIDEVTSTNI MSTPVESLNV TMNIDLRQTT FDSLVSSHIA
WHTNIRQQYP TARIGIICNT VRRAQDIARE LQLRGEHVLL LHSRMTAEHR RQTATQLLDL
VGPKGTGENI TVIGTQAIEA SLDIDLDFLN SEICPAPSLV QRAGRQWRHP DPHRSERCPN
EKEKTLTITW FESDEDGQYL PYLAAELRRT YTWLSNHKQL IIPDHAQDFI DSAHVDFTNA
ETDSDHDALT QNLLKSMRGD SNRAEISAAL EPHAEVSKFS GLTTDNPADE STTRLIDQGS
QARLIMGSVS GKIPGSWKGT PEELLALTSQ DKEQIRHALR ASMPLYLARS QGREEYLAEH
DMISLAGSRS LLAGYYFMPQ ADRWYDELLG FTDRDESDKG L
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