ID D7BZ19_STRBB Unreviewed; 769 AA.
AC D7BZ19;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=MMPL domain-containing protein {ECO:0000313|EMBL:ADI05728.1};
GN OrderedLocusNames=SBI_02607 {ECO:0000313|EMBL:ADI05728.1};
OS Streptomyces bingchenggensis (strain BCW-1).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI05728.1, ECO:0000313|Proteomes:UP000000377};
RN [1] {ECO:0000313|EMBL:ADI05728.1, ECO:0000313|Proteomes:UP000000377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCW-1 {ECO:0000313|EMBL:ADI05728.1,
RC ECO:0000313|Proteomes:UP000000377};
RX PubMed=20581206; DOI=10.1128/JB.00596-10;
RA Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA Xiang W.S.;
RT "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT bingchenggensis.";
RL J. Bacteriol. 192:4526-4527(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP002047; ADI05728.1; -; Genomic_DNA.
DR RefSeq; WP_014175205.1; NC_016582.1.
DR AlphaFoldDB; D7BZ19; -.
DR STRING; 749414.SBI_02607; -.
DR KEGG; sbh:SBI_02607; -.
DR PATRIC; fig|749414.3.peg.2701; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_5_1_11; -.
DR Proteomes; UP000000377; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000377};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 181..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 692..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..337
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 740..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 769 AA; 81684 MW; F05DA1EECBFDF93D CRC64;
MLDRLARAIV RRPRAFLIAV LGFMLIAGPL GGPVVGKLVN GGFEDPKSES SLAKQALDQH
FGVKDSNLVL LVRAPGSVDS DPAAEDGAAL TRRLAAEPGI SQVGSYWSQG RDQRLRSEDS
RYAMVIGHIG GGENAAADRV EGLRKEFAGR QGSLDVKLGG STAMGFDTDH TVQKDLQRME
AIAFPVLFVI LLLVFGSLIS ALLPLLMVLP LLLGTLLMLR TITLFTDVSV FALNVTTIIG
LGIAIDYSLF IVTRYREEIR DRGGDLTDKQ VRSEAIVAAV RTAGRTVVFS AVTVMLSMAA
LALFPLLFLR SIAVAGIGVM LFAALAATIV MPMLLALFGS KIDSLDLRKG VRRLLGRPPR
PRAELERGVW HRLATFVMRF AAPVAVVATA ALLLLGAPFL GAEYSLPDDR QLPKTAQSRQ
VGDVIREDFV SREADVIAIV ATGIGDPKQQ SAAIGAYAER ISKLDGVESV ASSAGVFAHG
ARVAPPGPAT ASLAAKSATY LRVSPDVEPF SAAGERLVHD IRGADSPWPV RVAGGGPALV
DTLDALGDRM PMVLGFMMLS TFVLLFLFTG SLLLPLKALV LNALSLSATF GAVVWIFQEG
HLAGALDATV TGSLIALTPI LMFCLMFGLS MDYEVFMLSR IKEEYERTGD NTAAVARGLE
LTGRLVTAAA LLLGMVMVVS LFTAQITFQK MLGLGLTVAL VVDTLVVRGL LLPAFMRLAG
SANWWAPGPL RRVHRRFGLS EAPKRTGQGH PAKAPSAAKE PDVPATAGS
//
