ID D7E864_METEZ Unreviewed; 211 AA.
AC D7E864;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Translation initiation factor 2 subunit beta {ECO:0000256|ARBA:ARBA00022314, ECO:0000256|HAMAP-Rule:MF_00232};
DE AltName: Full=aIF2-beta {ECO:0000256|ARBA:ARBA00031466, ECO:0000256|HAMAP-Rule:MF_00232};
DE AltName: Full=eIF-2-beta {ECO:0000256|ARBA:ARBA00032408, ECO:0000256|HAMAP-Rule:MF_00232};
GN Name=eif2b {ECO:0000256|HAMAP-Rule:MF_00232};
GN OrderedLocusNames=Metev_0493 {ECO:0000313|EMBL:ADI73406.1};
OS Methanohalobium evestigatum (strain ATCC BAA-1072 / DSM 3721 / NBRC 107634
OS / OCM 161 / Z-7303).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanohalobium.
OX NCBI_TaxID=644295 {ECO:0000313|EMBL:ADI73406.1, ECO:0000313|Proteomes:UP000000391};
RN [1] {ECO:0000313|EMBL:ADI73406.1, ECO:0000313|Proteomes:UP000000391}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1072 / DSM 3721 / NBRC 107634 / OCM 161 / Z-7303
RC {ECO:0000313|Proteomes:UP000000391};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Anderson I.,
RA Woyke T.;
RT "Complete sequence chromosome of Methanohalobium evestigatum Z-7303.";
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA.
CC {ECO:0000256|ARBA:ARBA00003323, ECO:0000256|HAMAP-Rule:MF_00232}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000256|ARBA:ARBA00011243, ECO:0000256|HAMAP-Rule:MF_00232}.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family.
CC {ECO:0000256|ARBA:ARBA00010397, ECO:0000256|HAMAP-Rule:MF_00232}.
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DR EMBL; CP002069; ADI73406.1; -; Genomic_DNA.
DR AlphaFoldDB; D7E864; -.
DR STRING; 644295.Metev_0493; -.
DR KEGG; mev:Metev_0493; -.
DR HOGENOM; CLU_026663_3_0_2; -.
DR Proteomes; UP000000391; Chromosome.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.30.170; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_00232; eIF_2_beta; 1.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004458; TIF2_bsu_arc.
DR InterPro; IPR002792; TRAM_dom.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR NCBIfam; TIGR00311; aIF-2beta; 1.
DR PANTHER; PTHR23001; EUKARYOTIC TRANSLATION INITIATION FACTOR; 1.
DR PANTHER; PTHR23001:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR Pfam; PF01938; TRAM; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF100966; Translation initiation factor 2 beta, aIF2beta, N-terminal domain; 1.
DR SUPFAM; SSF75689; Zinc-binding domain of translation initiation factor 2 beta; 1.
DR PROSITE; PS50926; TRAM; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_00232};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00232}; Reference proteome {ECO:0000313|Proteomes:UP000000391}.
FT DOMAIN 153..211
FT /note="TRAM"
FT /evidence="ECO:0000259|PROSITE:PS50926"
SQ SEQUENCE 211 AA; 23399 MW; BD3EBE57D2DC5E4C CRC64;
MINIEVDYND YDSLLDRAME KMPEMETSDD RFTIPEPKVL QEGKTTILDN FGNIVDVLNR
DPEHVLKYLN RELGTAGKIE GSRAVFQGRF PKELIKSNLD SYLNEYVLCT ECGRPDTQLE
KVDRVLVMKC LACGAHRPIK KKKASSGTTP TVAVEEGKVY DVQITAVGSK GDGIAKLDKF
TIFVPGAAKG QNVKVKINRI SGNLAFAEKA E
//
