ID D7EYH9_9EUKA Unreviewed; 307 AA.
AC D7EYH9;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Scs alpha {ECO:0000313|EMBL:ABU95432.1};
DE Flags: Fragment;
OS Sawyeria marylandensis.
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Psalteriomonadidae; Sawyeria.
OX NCBI_TaxID=194530 {ECO:0000313|EMBL:ABU95432.1};
RN [1] {ECO:0000313|EMBL:ABU95432.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21037180; DOI=10.1128/EC.00122-10;
RA Barbera M.J., Ruiz-Trillo I., Tufts J.Y., Bery A., Silberman J.D.,
RA Roger A.J.;
RT "Sawyeria marylandensis (Heterolobosea) has a hydrogenosome with novel
RT metabolic properties.";
RL Eukaryot. Cell 9:1913-1924(2010).
CC -!- SIMILARITY: Belongs to the succinate/malate CoA ligase alpha subunit
CC family. {ECO:0000256|RuleBase:RU000677}.
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DR EMBL; EF612760; ABU95432.1; -; mRNA.
DR AlphaFoldDB; D7EYH9; -.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.261; Succinyl-CoA synthetase domains; 1.
DR HAMAP; MF_01988; Succ_CoA_alpha; 1.
DR InterPro; IPR017440; Cit_synth/succinyl-CoA_lig_AS.
DR InterPro; IPR033847; Citrt_syn/SCS-alpha_CS.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR005810; CoA_lig_alpha.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005811; SUCC_ACL_C.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR NCBIfam; TIGR01019; sucCoAalpha; 1.
DR PANTHER; PTHR11117:SF2; SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11117; SUCCINYL-COA LIGASE SUBUNIT ALPHA; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF00549; Ligase_CoA; 1.
DR PIRSF; PIRSF001553; SucCS_alpha; 1.
DR PRINTS; PR01798; SCOASYNTHASE.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52210; Succinyl-CoA synthetase domains; 1.
DR PROSITE; PS01216; SUCCINYL_COA_LIG_1; 1.
DR PROSITE; PS00399; SUCCINYL_COA_LIG_2; 1.
PE 2: Evidence at transcript level;
KW Ligase {ECO:0000256|RuleBase:RU000677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT DOMAIN 22..118
FT /note="CoA-binding"
FT /evidence="ECO:0000259|SMART:SM00881"
FT ACT_SITE 267
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001553-1"
FT NON_TER 307
FT /evidence="ECO:0000313|EMBL:ABU95432.1"
SQ SEQUENCE 307 AA; 32285 MW; 99B0BF5B88DA9636 CRC64;
MLKNLTKFFS ATSVALTKPY VLINKDTKVI CQGITGNQGS FHSQQMINYG TKMVGGVNPK
KVGEKHLGLP IFKDVRQAVK ETGCHASMVF VPPPAGAAAI MEGIEAEIPL IVCITEGIPQ
HDMVKVVSAL KTQKKTRLVG PNCPGVIKPN ECKIGIMPGY IHKKGKIGIV SRSGTLTYEA
VSQTTAAGLG QSTVVGIGGD PFNGTNFIDV LDMFLHDPET EGIIMIGEIG GQAEEMAAHF
LDISPIKKPV VGFIAGVTAP PGRRMGHAGA VISGGNGDAK SIMAAMEKVG IRMSATPAKM
GTTMVQY
//
